Sunday, May 26, 2013 4:54am EDT

O'Neil Patrick R. - Insider Transactions

C/o Isis Pharmaceuticals, Inc.
2855 Gazelle Court
Carlsbad, CA 92010
CIK: 1564926

SEC Form 4

Date

Sym

Company

Insider

Title

Shares

Transaction

Value
MApr 19 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel42,320Option exercise at $13.83$585,141
MApr 19 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel42,320Sale at $21.50$910,028
MApr 12 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel5,460Option exercise at $14.24$77,751
MApr 12 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel5,460Sale at $19.61$107,096
Mar 21 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel9,000Option exercise at $14.18$127,620
Mar 21 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel9,000Sale at $19.26$173,340
MMar 4 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel11,700Option exercise at $11.25$131,657
MMar 4 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel11,700Sale at $15.82$185,059
MFeb 15 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel1,950Option exercise at $10.29$20,066
MFeb 15 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel1,950Sale at $14.80$28,865
MFeb 13 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel6,100Option exercise at $7.36$44,900
MFeb 13 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel6,239Sale at $14.17$88,407
MJan 29 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel2,300Sale at $14.63$33,660
Jan 30 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel2,000Option exercise at $10.29$20,580
Jan 15 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel542Option exercise at $0.00$0
Jan 17 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel242Sale at $14.16$3,427
Jan 4 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel1,296Sale at $10.76$13,945
Jan 1 2013
ISISIsis Pharmaceuticals IncO'Neil Patrick R.SVP, Legal, General Counsel431Other Purchase at $8.87$3,825
D Derivative transaction exists
M Multiple transactions summarized; earliest reported transaction date and average weighted transaction price
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