Insider Stock Trading

Filing Date	T Date	Ticker	Issuer	Inc	Sector	Ind	Industry	Owner	oSt	Rel	Title	#f	T	TVal	Price	Qty	oc	Own	H
9/25/25 20:59	9/23/25	ALZN	Alzamend Neuro, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ault Milton C III	NV	DT		6	S.dm	-1,092	2.48	-440		124	I
9/25/25 19:44	9/23/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Lyssikatos Joseph P	CO	O	CHIEF SC	4	S.m	-693	20.67	-34		953	I
9/25/25 19:42	9/23/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kintz Samuel	CO	DO	P,CEO	5	S.m	-704	20.82	-34		940	I
9/25/25 16:40	9/24/25	PRAX	Praxis Precision Medicines, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Mitchell Dean J	MA	D		1	M.d	484	39.51	12	245	17	D
9/25/25 16:31	7/25/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Causey Christopher	MD	D		5	M.d	2,226	242.25	9		5	D
9/25/25 16:30	9/23/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Rothblatt Martine A	MD	DO	CHAIRPER	14	M.dm	27,375	263.22	104	19	644	D
9/25/25 16:30	9/23/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Rothblatt Martine A	MD	DO	CHAIRPER	14	S.dm	-27,375	263.22	-104		644	D
9/24/25 20:35	9/22/25	PTGX	Protagonist Therapeutics, Inc	DE	Health	Drug	Pharmaceutical Preparations	Waddill William D.	CA	D		2	S	-494	61.75	-8		9	D
9/24/25 19:42	9/22/25	OKUR	Onkure Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Saccomano Nicholas A	CO	DO	P,CEO	1	S	0	2.63	0		4	D
9/24/25 19:41	9/22/25	OKUR	Onkure Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Leverone Jason A.	CO	O	CFO	1	S	-1	2.62	0		13	D
9/24/25 19:00	9/24/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Bush Tia L	X0	O	Chief Te	4	M.dm	2,650	15.62	170		122	D
9/24/25 19:00	9/24/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Bush Tia L	X0	O	Chief Te	4	S.dm	-2,650	15.62	-170		122	D
9/24/25 18:49	9/12/25	BYSI	Beyondspring Inc.		Health	Drug	Pharmaceutical Preparations	Decheng Capital China Life Sciences Usd Fund Iii, L.P.	CA	T		11	S.m	-1,456	2.77	-526		4,488	I
9/24/25 17:11	9/23/25	LGND	Ligand Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Aryeh Jason	FL	D		1	S	-1,708	170.81	-10		126	D
9/24/25 16:30	9/22/25	ORIC	Oric Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Chacko Jacob	CA	DO	P,CEO	1	S	-1,350	10.80	-125		656	D
9/24/25 16:30	9/22/25	VSTM	Verastem, Inc.	MA	Health	Drug	Pharmaceutical Preparations	Calkins Daniel	MA	O	CFO	1	S.m	-1	9.12	0	0	110	D
9/24/25 16:14	8/6/25	SUPN	Supernus Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Khattar Jack A.	MD	DO	P,CEO	16	M.dm	20,010	28.47	703	49	2,146	D
9/24/25 16:14	8/6/25	SUPN	Supernus Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Khattar Jack A.	MD	DO	P,CEO	16	S.dm	-20,010	28.47	-703		2,146	D
9/24/25 16:05	9/22/25	TVTX	Travere Therapeutics, Inc.	CA	Health	Drug	Pharmaceutical Preparations	Reed Elizabeth E	CA	O	GC,GC	2	M.d	441	22.04	20	29	90	D
9/24/25 16:05	9/22/25	TVTX	Travere Therapeutics, Inc.	CA	Health	Drug	Pharmaceutical Preparations	Reed Elizabeth E	CA	O	GC,GC	2	S.d	-441	22.04	-20		90	D
9/24/25 09:16	9/22/25	ARVN	Arvinas, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Morrison Briggs	CT	D		1	P	227	7.57	30	65	76	D
9/24/25 06:35	9/22/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Benkowitz Michael	MD	O	P,COO	8	M.dm	48,867	291.31	168		3	I
9/24/25 06:35	9/22/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Benkowitz Michael	MD	O	P,COO	8	S.dm	-48,867	291.31	-168		3	I
9/23/25 21:00	9/19/25	ROIV	Roivant Sciences Ltd.	D0	Health	Drug	Pharmaceutical Preparations	Venker Eric	X0	O	P,Immuno	6	M.dm	34,634	9.43	3,673		1,654	D
9/23/25 21:00	9/19/25	ROIV	Roivant Sciences Ltd.	D0	Health	Drug	Pharmaceutical Preparations	Venker Eric	X0	O	P,Immuno	6	S.dm	-34,634	9.43	-3,673		1,654	D
9/23/25 17:32	9/19/25	XOMA	Xoma Royalty Corp	NV	Health	Drug	Pharmaceutical Preparations	Sitko Bradley	CA	O	Chief In	2	M.d	51	5.83	9	38	32	D
9/23/25 17:32	9/19/25	XOMA	Xoma Royalty Corp	NV	Health	Drug	Pharmaceutical Preparations	Hughes Owen	CA	DO	CEO	1	M.d	0	0.00	36	55	101	D
9/23/25 17:32	9/19/25	XOMA	Xoma Royalty Corp	NV	Health	Drug	Pharmaceutical Preparations	Burns Thomas M.	CA	O	SVP,Fina	2	M.d	156	9.63	16	67	40	D
9/23/25 17:32	9/22/25	XOMA	Xoma Royalty Corp	NV	Health	Drug	Pharmaceutical Preparations	Burns Thomas M.	CA	O	SVP,Fina	2	S.d	-156	9.63	-16		40	D
9/23/25 17:32	9/19/25	XOMA	Xoma Royalty Corp	NV	Health	Drug	Pharmaceutical Preparations	Montano Maricel Perea	CA	O	GC	2	M.d	0	0.00	12		12	D
9/23/25 17:07	9/9/25	CYTK	Cytokinetics Inc		Health	Drug	Pharmaceutical Preparations	Malik Fady Ibraham	CA	O	EVP Rese	12	M.d	620	25.84	24	21	141	D
9/23/25 17:07	9/9/25	CYTK	Cytokinetics Inc		Health	Drug	Pharmaceutical Preparations	Malik Fady Ibraham	CA	O	EVP Rese	12	S.d	-620	25.84	-24		141	D
9/23/25 16:57	9/22/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hughes Steven George	CA	O	Chief Me	10	M.d	4,459	30.99	144		39	D
9/23/25 16:57	9/22/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hughes Steven George	CA	O	Chief Me	10	S.d	-4,459	30.99	-144		39	D
9/23/25 16:33	9/19/25	LVTX	Lava Therapeutics Nv	P7	Health	Drug	Pharmaceutical Preparations	Versant Venture Capital Vi, L.P.	CA	T		2	S.m	-6,571	1.43	-4,588		2,903	M
9/23/25 16:06	9/22/25	SAVA	Cassava Sciences Inc	DE	Health	Drug	Pharmaceutical Preparations	Barry Richard	TX	DO	P,CEO	2	P.m	551	2.25	245	52	715	I
9/22/25 19:49	7/9/25	ABEO	Abeona Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	O'Malley Brendan M.	OH	O	SVP,GC	2	S	-106	5.84	-18		361	D
9/22/25 19:00	9/22/25	AXSM	Axsome Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Jacobson Mark L.	NY	O	COO	4	M.d	6,626	62.64	106		0	D
9/22/25 19:00	9/22/25	AXSM	Axsome Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Jacobson Mark L.	NY	O	COO	4	S.d	-6,626	62.64	-106	-100	0	D
9/22/25 18:32	9/9/25	PAHC	Phibro Animal Health Corp	DE	Health	Drug	Pharmaceutical Preparations	Bendheim Jack	NJ	DOT	P,CEO	2	S.dm	-1,140	40.51	-28		78	I
9/22/25 17:25	9/19/25	AQST	Aquestive Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Barber Daniel	NJ	DO	P,CEO	1	S	-2	6.00	0	0	1,015	D
9/22/25 17:14	9/19/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Davis Krista	MN	O	SVP,CHRO	2	S	-259	93.61	-3		63	D
9/22/25 16:00	7/24/25	LLY	Eli Lilly & Co	IN	Health	Drug	Pharmaceutical Preparations	Lilly Endowment Inc	IN	T		3	S	-325,010	792.14	-410	0	95,737	D
9/22/25 09:35	9/18/25	CALC	Calcimedica, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Roberts Eric W	CA	DOT	CHIEF BU	14	P.dm	164	2.48	66	7	1,064	I
9/19/25 21:17	9/19/25	APLS	Apellis Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Dunlop A. Sinclair	MA	D		1	S	-714	22.95	-31		223	I
9/19/25 20:46	9/17/25	PGEN	Precigen, Inc.	VA	Health	Drug	Pharmaceutical Preparations	Kirk Randal J	VA	DT		2	M.dm	18,654	0.8333	22,386	21	128,722	I
9/19/25 20:46	9/18/25	PGEN	Precigen, Inc.	VA	Health	Drug	Pharmaceutical Preparations	Kirk Randal J	VA	DT		2	S.dm	-18,654	0.8333	-22,386		128,722	I
9/19/25 18:23	9/18/25	RARE	Ultragenyx Pharmaceutical Inc.	DE	Health	Drug	Pharmaceutical Preparations	Huizenga Theodore Alan	CA	O	SVP,Chie	2	S	-5	30.43	0	0	50	D
9/19/25 16:49	9/19/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Olian Judy D.	MD	D		2	S.d	-748	250.09	-3		7	D
9/19/25 16:05	9/4/25	RAPP	Rapport Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ceesay Abraham	MA	DO	CEO	2	S	-2,075	26.34	-79		722	D
9/18/25 21:45	9/16/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Duncan Gregory Scott	NJ	D		1	M.d	111	8.32	13	53	38	D
9/18/25 21:30	9/16/25	OLMA	Olema Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Harmon Cyrus	CA	D		1	S.m	-205	8.19	-25		861	M
9/18/25 19:28	9/18/25	ROIV	Roivant Sciences Ltd.	D0	Health	Drug	Pharmaceutical Preparations	Gline Matthew	X0	DO	CEO	1	P	50	15.07	3	0	17,287	D
9/18/25 18:16	9/16/25	VSTM	Verastem, Inc.	MA	Health	Drug	Pharmaceutical Preparations	Stuglik Brian M	MA	D		1	S	-6	9.99	-1		102	D
9/18/25 18:14	9/16/25	VSTM	Verastem, Inc.	MA	Health	Drug	Pharmaceutical Preparations	Gagnon Robert E.	MA	D		1	S	-3	9.99	0		42	D
9/18/25 18:11	9/16/25	VSTM	Verastem, Inc.	MA	Health	Drug	Pharmaceutical Preparations	Paterson Dan	MA	DO	P,CEO	2	S	-12	6.76	-2	0	443	D
9/18/25 16:45	7/9/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Oyler John	V8	DO	CEO	2	S	-16,100	289.55	-56	0	53,868	D
9/18/25 16:36	9/16/25	LFVN	Lifevantage Corp		Health	Drug	Pharmaceutical Preparations	Lewis Darwin	UT	D		1	P	5	10.85	0	0	117	D
9/18/25 16:31	8/21/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Mahon Paul A	MD	O	EVP,GC	12	M.d	30,988	234.76	132		37	D
9/18/25 16:31	8/21/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Mahon Paul A	MD	O	EVP,GC	12	S.d	-30,988	234.76	-132		37	D
9/18/25 16:23	9/16/25	ALXO	Alx Oncology Holdings Inc	DE	Health	Drug	Pharmaceutical Preparations	Lettmann Jason	CA	DO	CEO	2	P.m	101	1.07	95	45	305	D
9/18/25 16:06	9/17/25	ESPR	Esperion Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Looker Benjamin	MI	O	GC	2	S	-19	2.52	-8		400	D
9/18/25 16:06	9/17/25	ESPR	Esperion Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Koenig Sheldon L.	MI	DO	P,CEO	1	S	-79	2.79	-28		1,519	D
9/18/25 16:06	9/17/25	ESPR	Esperion Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Halladay Benjamin	MI	O	CFO	2	S	-20	2.81	-7		475	D
9/18/25 16:01	9/16/25	APLS	Apellis Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Watson David O.	MA	O	GC	4	S	-882	25.20	-35		209	D
9/17/25 20:08	9/15/25	APLS	Apellis Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Chopas James George	MA	O	VP,Chief	2	S	-20	27.08	-1		54	D
9/17/25 19:39	9/16/25	MNKD	Mannkind Corp	DE	Health	Drug	Pharmaceutical Preparations	Tross Stuart A	CT	O	Chief Pe	1	S	-251	5.34	-47		1,032	D
9/17/25 18:58	9/17/25	NRIX	Nurix Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Gregory Julia P	CA	D		1	M.d	20	1.86	11		11	D
9/17/25 18:06	9/16/25	TNGX	Tango Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Third Rock Ventures Iv, L.P.	MA	T		4	S.m	-17,496	7.01	-2,495		15,759	D
9/17/25 17:22	9/8/25	NAMS	Newamsterdam Pharma Co N.V.	P7	Health	Drug	Pharmaceutical Preparations	Topper James N	CA	D		3	P	58	24.43	2	0	6,830	I
9/17/25 17:20	9/17/25	IMMX	Immix Biopharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rachman Ilya M	CA	DO	CEO,CB	1	P	5	2.02	3	0	1,141	D
9/17/25 17:20	9/16/25	IMMX	Immix Biopharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Morris Gabriel S	CA	DO	CFO	1	P	5	1.97	3	0	586	D
9/17/25 17:01	9/15/25	BCAX	Bicara Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Meisner Lara	MA	O	GC	2	M.d	268	8.47	32		0	D
9/17/25 17:01	9/15/25	BCAX	Bicara Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Meisner Lara	MA	O	GC	2	S.d	-268	8.47	-32	-100	0	D
9/17/25 16:45	9/15/25	KNSA	Kiniksa Pharmaceuticals International, Plc	X0	Health	Drug	Pharmaceutical Preparations	Tessari Eben	X0	O	COO	12	M.dm	13,854	23.73	584		50	D
9/17/25 16:45	9/15/25	KNSA	Kiniksa Pharmaceuticals International, Plc	X0	Health	Drug	Pharmaceutical Preparations	Tessari Eben	X0	O	COO	12	S.dm	-13,854	23.73	-584		50	D
9/17/25 16:31	8/15/25	NUVL	Nuvalent, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Porter James Richard	MA	DO	P,CEO	6	M.d	7,926	48.93	162	186	249	D
9/17/25 16:31	8/15/25	NUVL	Nuvalent, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Porter James Richard	MA	DO	P,CEO	6	S.d	-7,926	48.93	-162		249	D
9/17/25 16:30	9/15/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Singh Raman	NC	D		3	M.d	1,511	15.34	99		31	D
9/17/25 16:30	9/15/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Singh Raman	NC	D		3	S.d	-1,511	15.34	-99		31	D
9/17/25 16:15	9/15/25	RAPP	Rapport Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bredt David	MA	O	Chief Sc	3	S	-452	17.73	-26		435	D
9/17/25 16:03	9/15/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	McCarthy Teresa	CA	O	CHRO	4	M.d	1,645	32.91	50	106	97	D
9/17/25 16:03	9/15/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	McCarthy Teresa	CA	O	CHRO	4	S.d	-1,645	32.91	-50		97	D
9/17/25 16:02	9/15/25	ANAB	Anaptysbio, Inc	DE	Health	Drug	Pharmaceutical Preparations	Orwin John A	CA	D		1	M.d	0	0.00	1	14	11	D
9/16/25 21:45	9/12/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Dunton Alan W	NJ	D		2	M.d	167	8.34	20	99	40	D
9/16/25 21:45	9/12/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Dunton Alan W	NJ	D		2	S.d	-167	8.34	-20		40	D
9/16/25 21:21	9/10/25	BFRI	Biofrontera Inc.	DE	Health	Drug	Pharmaceutical Preparations	Luebbert Hermann	MA	DO	CEO,CB	1	M.d	0	0.00	138	904	153	D
9/16/25 21:19	9/10/25	BFRI	Biofrontera Inc.	DE	Health	Drug	Pharmaceutical Preparations	Leffler Eugene Frederick	MA	O	CFO	1	M.d	0	0.00	88		88	D
9/16/25 19:36	9/12/25	AXSM	Axsome Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Tabuteau Herriot	NY	DOT	CEO	2	M.dm	7,866	62.55	126	2	7,352	D
9/16/25 19:36	9/12/25	AXSM	Axsome Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Tabuteau Herriot	NY	DOT	CEO	2	S.dm	-7,866	62.55	-126		7,352	D
9/16/25 19:05	9/14/25	BTAI	Bioxcel Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Mehta Vimal	CT	DO	CEO,P	1	M.dm	0	0.00	0	0	501	D
9/16/25 19:04	9/14/25	BTAI	Bioxcel Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Steinhart Richard I	CT	O	CFO	2	M.dm	0	0.00	1	12	7	D
9/16/25 19:02	9/14/25	BTAI	Bioxcel Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rodriguez Javier	CT	O	See Rema	2	M.dm	0	0.00	1	11	7	D
9/16/25 19:00	9/14/25	BTAI	Bioxcel Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Yocca Frank	CT	O	Chief Sc	1	M.dm	0	0.00	0	1	6	D
9/16/25 18:54	8/12/25	MLYS	Mineralys Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rodman David Malcom	PA	O	Chief Me	5	M.d	736	15.72	47	92	98	D
9/16/25 18:54	8/13/25	MLYS	Mineralys Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rodman David Malcom	PA	O	Chief Me	5	S.d	-736	15.72	-47		98	D
9/16/25 18:16	7/29/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Accardi Mario Alberto	X0	O	P,Orexin	4	S.d	-482	16.90	-28		208	D
9/16/25 18:09	9/12/25	LBRX	Lb Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Deep Track Biotechnology Master Fund, Ltd.	E9	T		2	P.dm	62,352	13.18	4,732	33	19,079	M
9/16/25 18:06	9/12/25	ARWR	Arrowhead Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hamilton James C	CA	O	Chief Me	3	S.m	-1,025	25.63	-40		262	D
9/16/25 18:00	9/15/25	ACAD	Acadia Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Schneyer Mark C.	CA	O	EVP,CFO	2	S	-637	24.97	-25		43	D
9/16/25 16:56	9/12/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	6	M.dm	12,288	54.57	225		57	D
9/16/25 16:56	9/12/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	6	S.dm	-12,288	54.57	-225		57	D
9/16/25 16:35	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Paulson Richard A.	MA	DO	P,CEO	1	S	-8	6.43	-1		84	D
9/16/25 16:34	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Mano Michael	MA	O	SVP,GC,S	1	S	-2	6.43	0		21	D
9/16/25 16:33	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Poulton Stuart	MA	O	EVP,Chie	2	S	-3	5.77	-1		28	D
9/16/25 16:32	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rangwala Reshma	MA	O	EVP,Chie	1	S	-3	6.43	0		29	D
9/16/25 16:31	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Cheng Sohanya Roshan	MA	O	EVP,Chie	1	S	-2	6.43	0		36	D
9/16/25 16:30	9/3/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Abate Kristin	MA	O	Chief Ac	3	S	-1	4.33	0		10	D
9/16/25 16:15	9/12/25	ZVRA	Zevra Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Favorito Tamara A	FL	D		1	P	25	7.79	3	442	4	D
9/16/25 16:15	9/12/25	LBRX	Lb Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Pontifax Management 4 G.P. (2015) Ltd.	NY	T		1	P.d	15,000	15.00	1,000	243	1,412	I
9/16/25 16:15	9/12/25	LBRX	Lb Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Nussbaum Ran	NY	D		1	P.d	15,000	15.00	1,000	243	1,412	I
9/16/25 15:46	9/12/25	LBRX	Lb Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Vida Ventures Gp Iii, L.L.C.	CA	T		1	P.d	5,000	15.00	333	61	884	I
9/16/25 06:15	9/15/25	AARD	Aardvark Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Lee Tien-Li	CA	DOT	CEO	3	P.dm	330	7.00	47	2	3,017	D
9/15/25 20:12	9/11/25	CAMP	Camp4 Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	5Am Partners Vi, LLC	CA	T		1	P	4,500	1.53	2,941	100	5,869	I
9/15/25 19:16	9/12/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Cook Meredith	MN	O	SVP,GC,S	3	S	-101	84.06	-1		79	D
9/15/25 18:37	8/15/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Hussain Iqbal J	X0	O	GC	8	M.dm	1,503	12.96	116		111	D
9/15/25 18:37	8/15/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Hussain Iqbal J	X0	O	GC	8	S.dm	-1,503	12.96	-116		111	D
9/15/25 17:39	9/12/25	SUPN	Supernus Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Mottola Frank	MD	O	SVP,Chie	4	M.d	1,231	32.40	38		15	D
9/15/25 17:39	9/12/25	SUPN	Supernus Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Mottola Frank	MD	O	SVP,Chie	4	S.d	-1,231	32.40	-38		15	D
9/15/25 16:47	9/2/25	CYTK	Cytokinetics Inc		Health	Drug	Pharmaceutical Preparations	Blum Robert I	CA	DO	P,CEO	6	S	-1,226	40.85	-30		402	D
9/15/25 16:26	9/11/25	MRSN	Mersana Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Huber Martin H. Jr.	MA	DO	P,CEO	2	M.d	15	1.69	9	976	10	D
9/15/25 16:26	9/12/25	MRSN	Mersana Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Huber Martin H. Jr.	MA	DO	P,CEO	2	S.d	-15	1.69	-9		10	D
9/15/25 16:23	9/12/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Schaeffer Orlov S Nicole	NJ	O	Chief Pe	3	M.d	13,746	96.10	143		80	D
9/15/25 16:23	9/12/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Schaeffer Orlov S Nicole	NJ	O	Chief Pe	3	S.d	-13,746	96.10	-143		80	D
9/15/25 16:22	9/12/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Sharoky Melvin Md	NJ	D		3	S	-3,965	132.16	-30		334	M
9/15/25 16:07	9/12/25	ZVRA	Zevra Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Shih Alvin	FL	D		1	P	158	7.89	20		20	D
9/15/25 16:05	9/12/25	RAPP	Rapport Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Huber Reid M	MA	D		1	P	499	24.48	20		20	D
9/15/25 16:05	9/12/25	RAPP	Rapport Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Paul Steven M	MA	D		1	P	1,027	24.65	42		42	I
9/15/25 12:45	9/12/25	GALT	Galectin Therapeutics Inc	NV	Health	Drug	Pharmaceutical Preparations	Callicutt Jack W	GA	O	CFO	2	M.d	68	3.90	17		8	D
9/15/25 12:45	9/12/25	GALT	Galectin Therapeutics Inc	NV	Health	Drug	Pharmaceutical Preparations	Callicutt Jack W	GA	O	CFO	2	S.d	-68	3.90	-17		8	D
9/15/25 12:45	9/12/25	GALT	Galectin Therapeutics Inc	NV	Health	Drug	Pharmaceutical Preparations	Lewis Joel	GA	DO	P,CEO	2	M.d	123	4.38	28	3	835	D
9/15/25 12:45	9/12/25	GALT	Galectin Therapeutics Inc	NV	Health	Drug	Pharmaceutical Preparations	Lewis Joel	GA	DO	P,CEO	2	S.d	-123	4.38	-28		835	D
9/12/25 21:45	9/12/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Todisco Joseph	NJ	O	CEO	2	M.d	824	8.24	100	24	509	D
9/12/25 21:45	9/12/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Todisco Joseph	NJ	O	CEO	2	S.d	-824	8.24	-100		509	D
9/12/25 20:39	9/2/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Young Jonathan	CA	O	COO	5	M.d	1,726	34.12	51	24	257	D
9/12/25 20:39	9/2/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Young Jonathan	CA	O	COO	5	S.d	-1,726	34.12	-51		257	D
9/12/25 20:39	9/11/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Yale Catriona	CA	O	Chief De	3	S.d	-757	36.62	-21		91	D
9/12/25 20:38	9/11/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	White William Richard	CA	O	CFO	1	S	-28	43.02	-1		58	D
9/12/25 20:36	9/8/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rolph Timothy	CA	O	Chief Sc	7	M.d	2,548	33.72	76	83	167	D
9/12/25 20:36	9/8/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rolph Timothy	CA	O	Chief Sc	7	S.d	-2,548	33.72	-76		167	D
9/12/25 20:36	9/10/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Cheng Andrew	CA	DO	P,CEO	4	M.dm	4,488	42.05	107	26	521	D
9/12/25 20:36	9/10/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Cheng Andrew	CA	DO	P,CEO	4	S.dm	-4,488	42.05	-107		521	D
9/12/25 20:00	9/11/25	MIRM	Mirum Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Brege Laura	CA	D		2	M.d	1,520	44.70	34		16	D
9/12/25 20:00	9/11/25	MIRM	Mirum Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Brege Laura	CA	D		2	S.d	-1,520	44.70	-34		16	D
9/12/25 20:00	9/11/25	MIRM	Mirum Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bjerkholt Eric	CA	O	CFO	4	M.d	806	20.75	39	999%	40	D
9/12/25 20:00	9/12/25	MIRM	Mirum Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bjerkholt Eric	CA	O	CFO	4	S.d	-806	20.75	-39		40	D
9/12/25 18:00	9/11/25	VTRS	Viatris Inc	DE	Health	Drug	Pharmaceutical Preparations	Le Goff Corinne	PA	O	Chief Co	1	S	-72	10.25	-7		35	D
9/12/25 17:30	9/11/25	CYRX	Cryoport, Inc.	NV	Health	Drug	Pharmaceutical Preparations	Hariri Robert J	TN	D		3	M.d	419	5.23	80		51	D
9/12/25 17:30	9/11/25	CYRX	Cryoport, Inc.	NV	Health	Drug	Pharmaceutical Preparations	Hariri Robert J	TN	D		3	S.d	-419	5.23	-80		51	D
9/12/25 17:09	9/11/25	XERS	Xeris Biopharma Holdings, Inc.		Health	Drug	Pharmaceutical Preparations	Persky Marla	IL	D		1	S	-120	7.72	-16		148	D
9/12/25 17:09	9/10/25	PMVP	Pmv Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Orbimed Advisors LLC	NY	T		3	S.d	-11,264	1.41	-7,982		14,191	I
9/12/25 16:42	9/11/25	TGTX	Tg Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Lonial Sagar	NC	D		1	S	-672	32.24	-21		94	D
9/12/25 16:38	9/10/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Lee Chan Henry	V8	O	SVP,GC	5	S.d	-10,063	257.62	-39		266	D
9/12/25 16:38	9/10/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Lee Chan Henry	V8	O	SVP,GC	5	M.d	10,063	257.62	39	17	266	D
9/12/25 16:32	9/10/25	ZLAB	Zai Lab Ltd	E9	Health	Drug	Pharmaceutical Preparations	Smiley Joshua L	MA	O	See Rema	3	P.d	530	16.28	33	60	87	D
9/12/25 16:30	8/29/25	NUVL	Nuvalent, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Pelish Henry E.	MA	O	Chief Sc	7	M.dm	1,735	47.41	37	125	66	D
9/12/25 16:11	9/12/25	RARE	Ultragenyx Pharmaceutical Inc.	DE	Health	Drug	Pharmaceutical Preparations	Parschauer Karah Herdman	CA	O	EVP,GC	1	S	-76	31.17	-2		73	D
9/12/25 16:07	9/11/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Flanagan W. Michael	CA	O	Chief Sc	2	M.d	1,063	26.58	40	100	80	D
9/12/25 16:07	9/11/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Flanagan W. Michael	CA	O	Chief Sc	2	S.d	-1,063	26.58	-40		80	D
9/12/25 08:36	8/1/25	CPIX	Cumberland Pharmaceuticals Inc	TN	Health	Drug	Pharmaceutical Preparations	Young Caroline	TN	D		3	P.m	1	3.70	0	1	33	D
9/12/25 08:35	8/1/25	CPIX	Cumberland Pharmaceuticals Inc	TN	Health	Drug	Pharmaceutical Preparations	Jones James	TN	D		3	P.m	3	3.68	1	2	44	D
9/12/25 08:34	8/1/25	CPIX	Cumberland Pharmaceuticals Inc	TN	Health	Drug	Pharmaceutical Preparations	Kazimi A J	TN	DOT	CB,CEO	3	P.m	3	3.68	1	0	5,700	D
9/12/25 08:32	8/1/25	CPIX	Cumberland Pharmaceuticals Inc	TN	Health	Drug	Pharmaceutical Preparations	Krogulski Kenneth	TN	D		3	P.m	15	3.71	4	1	290	D
9/11/25 21:45	9/9/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Zelnick Kaufman Beth	NJ	O	GC	2	M.d	835	8.35	100	124	180	D
9/11/25 21:45	9/9/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Zelnick Kaufman Beth	NJ	O	GC	2	S.d	-835	8.35	-100		180	D
9/11/25 21:45	9/9/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hurlburt Elizabeth	NJ	O	COO	2	M.dm	790	7.32	108	157	177	D
9/11/25 21:45	9/9/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hurlburt Elizabeth	NJ	O	COO	2	S.dm	-790	7.32	-108		177	D
9/11/25 21:04	9/10/25	IMNM	Immunome Inc.	DE	Health	Drug	Pharmaceutical Preparations	Higgins Jack	WA	O	Chief Sc	1	M.d	30	1.35	22	117	41	D
9/11/25 21:01	9/9/25	NKTR	Nektar Therapeutics	DE	Health	Drug	Pharmaceutical Preparations	Robin Howard W	CA	DO	P,CEO	4	S.dm	-829	38.44	-22		69	D
9/11/25 20:38	9/10/25	CORT	Corcept Therapeutics Inc	DE	Health	Drug	Pharmaceutical Preparations	Swisher Daniel N Jr	CA	D		6	M.d	568	43.01	13		0	D
9/11/25 20:38	9/10/25	CORT	Corcept Therapeutics Inc	DE	Health	Drug	Pharmaceutical Preparations	Swisher Daniel N Jr	CA	D		6	S.d	-568	43.01	-13	-100	0	D
9/11/25 19:36	9/10/25	SMMT	Summit Therapeutics Inc.		Health	Drug	Pharmaceutical Preparations	Zanganeh Mahkam	FL	DOT	Co-CEO	1	P.m	5,985	17.69	338	0	591,832	I
9/11/25 19:32	9/10/25	SMMT	Summit Therapeutics Inc.		Health	Drug	Pharmaceutical Preparations	Duggan Robert W	FL	DOT	Co-CEO	1	P.m	5,985	17.69	338	0	591,832	D
9/11/25 18:57	9/9/25	LFVN	Lifevantage Corp		Health	Drug	Pharmaceutical Preparations	Beindorff Michael A	UT	D		1	S	-49	11.44	-4		120	M
9/11/25 18:13	9/11/25	RAPP	Rapport Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Young Wendy B.	MA	D		1	P	79	22.60	4	58	10	D
9/11/25 18:00	9/10/25	DRRX	Durect Corp	DE	Health	Drug	Pharmaceutical Preparations	Farfel Gail M	CA	D		1	M.d	7	1.22	6	55	16	D
9/11/25 18:00	9/9/25	IRON	Disc Medicine, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Quisel John D	MA	DO	CEO	5	M.d	2,616	29.07	90	110	172	D
9/11/25 17:52	9/9/25	DRRX	Durect Corp	DE	Health	Drug	Pharmaceutical Preparations	Brown James E	CA	DO	P,CEO	2	M.dm	354	1.30	272	97	553	D
9/11/25 17:50	9/10/25	DRRX	Durect Corp	DE	Health	Drug	Pharmaceutical Preparations	Robertson Judith J.	CA	D		1	M.d	7	1.22	6	15	41	D
9/11/25 17:48	9/9/25	DRRX	Durect Corp	DE	Health	Drug	Pharmaceutical Preparations	Garcia Peter S	CA	D		1	M.d	7	1.22	6	79	13	D
9/11/25 17:20	9/9/25	DNTH	Dianthus Therapeutics, Inc. /De/	DE	Health	Drug	Pharmaceutical Preparations	Savitz Ryan	NY	O	CFO,CBO	2	M.d	869	21.72	40		0	D
9/11/25 17:20	9/9/25	DNTH	Dianthus Therapeutics, Inc. /De/	DE	Health	Drug	Pharmaceutical Preparations	Savitz Ryan	NY	O	CFO,CBO	2	S.d	-869	21.72	-40	-100	0	D
9/11/25 17:10	9/9/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Wang Lai	V8	O	Global H	3	S.m	-3,262	326.17	-10		1,746	I
9/11/25 17:05	9/9/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Baroldi Joseph	CA	O	EVP,Chie	6	M.d	4,136	45.95	90		35	D
9/11/25 17:05	9/9/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Baroldi Joseph	CA	O	EVP,Chie	6	S.d	-4,136	45.95	-90		35	D
9/11/25 17:00	9/9/25	PRGO	Perrigo Co Plc	L2	Health	Drug	Pharmaceutical Preparations	Ball David	MI	O	EVP,CBDO	1	M.d	172	22.28	8		5	D
9/11/25 16:59	9/11/25	CAMP	Camp4 Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Polaris Management Co. Vii, L.L.C.	MA	T		1	P	2,000	1.53	1,307		1,107	I
9/11/25 16:48	9/11/25	CAMP	Camp4 Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Nashat Amir	MA	DT		1	P	2,000	1.53	1,307		1,107	I
9/11/25 16:25	9/11/25	CAMP	Camp4 Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Maricich Yuri	MA	O	Chief Me	1	P	10	1.65	6		6	D
9/11/25 16:24	9/11/25	CAMP	Camp4 Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Gold Kelly	MA	O	CFO	1	P	10	1.65	6	10	68	D
9/11/25 16:23	9/11/25	CAMP	Camp4 Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Mandel-Brehm Josh	MA	DO	CEO	1	P	10	1.65	6	2	278	D
9/11/25 16:22	9/11/25	CAMP	Camp4 Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Young Richard A	MA	D		1	P	25	1.65	15	10	170	D
9/11/25 16:16	9/10/25	BSPK	Bespoke Extracts, Inc.	NV	Health	Drug	Pharmaceutical Preparations	Feinsod Michael	NY	DOT	CEO	4	P.m	3	0.1600	17	1	2,512	D
9/11/25 16:05	9/9/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Reitan Colleen F	MA	D		2	M.d	10,228	284.12	36		1	D
9/11/25 16:05	9/9/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Reitan Colleen F	MA	D		2	S.d	-10,228	284.12	-36		1	D
9/11/25 13:14	9/9/25	DRRX	Durect Corp	DE	Health	Drug	Pharmaceutical Preparations	Maderis Gail J	CA	D		1	M.d	7	1.22	6	28	26	D
9/10/25 20:12	9/8/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Patel Anish	CO	O	COO	3	S	-389	19.43	-20		297	I
9/10/25 18:21	9/8/25	ARQT	Arcutis Biotherapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Watanabe Todd	CA	DO	See Rema	2	S.m	-343	15.83	-22		1,135	D
9/10/25 17:50	9/8/25	MIRM	Mirum Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ramasastry Saira	CA	D		2	M.d	400	11.76	34		0	D
9/10/25 17:50	9/8/25	MIRM	Mirum Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ramasastry Saira	CA	D		2	S.d	-400	11.76	-34	-100	0	D

D	Derivative transaction in filing (usually option exercise)
M	Multiple transactions in filing; earliest reported transaction date and weighted average transaction price
A	Amended filing
E	Error detected in filing

S - Sale	Sale of securities on an exchange or to another person
S - Sale+OE	Sale of securities on an exchange or to another person (after option exercise)
F - Tax	Payment of exercise price or tax liability using portion of securities received from the company
P - Purchase	Purchase of securities on an exchange or from another person

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