Insider Stock Trading

Filing Date	T Date	Ticker	Issuer	Inc	Sector	Ind	Industry	Owner	oSt	Rel	Title	#f	T	TVal	Price	Qty	oc	Own	H
9/25/25 20:59	9/23/25	ALZN	Alzamend Neuro, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ault Milton C III	NV	DT		6	S.dm	-1,092	2.48	-440		124	I
9/25/25 19:44	9/23/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Lyssikatos Joseph P	CO	O	CHIEF SC	4	S.m	-693	20.67	-34		953	I
9/25/25 19:42	9/23/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kintz Samuel	CO	DO	P,CEO	5	S.m	-704	20.82	-34		940	I
9/25/25 16:31	9/24/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Causey Christopher	MD	D		2	S.d	-1,710	427.41	-4		5	D
9/25/25 16:30	9/23/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Rothblatt Martine A	MD	DO	CHAIRPER	7	S.dm	-21,122	406.18	-52		644	D
9/24/25 20:35	9/22/25	PTGX	Protagonist Therapeutics, Inc	DE	Health	Drug	Pharmaceutical Preparations	Waddill William D.	CA	D		2	S	-494	61.75	-8		9	D
9/24/25 19:42	9/22/25	OKUR	Onkure Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Saccomano Nicholas A	CO	DO	P,CEO	1	S	0	2.63	0		4	D
9/24/25 19:41	9/22/25	OKUR	Onkure Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Leverone Jason A.	CO	O	CFO	1	S	-1	2.62	0		13	D
9/24/25 19:00	9/24/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Bush Tia L	X0	O	Chief Te	2	S.dm	-1,886	22.24	-85		122	D
9/24/25 18:49	9/12/25	BYSI	Beyondspring Inc.		Health	Drug	Pharmaceutical Preparations	Decheng Capital China Life Sciences Usd Fund Iii, L.P.	CA	T		11	S.m	-1,456	2.77	-526		4,488	I
9/24/25 17:11	9/23/25	LGND	Ligand Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Aryeh Jason	FL	D		1	S	-1,708	170.81	-10		126	D
9/24/25 16:30	9/22/25	ORIC	Oric Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Chacko Jacob	CA	DO	P,CEO	1	S	-1,350	10.80	-125		656	D
9/24/25 16:30	9/22/25	VSTM	Verastem, Inc.	MA	Health	Drug	Pharmaceutical Preparations	Calkins Daniel	MA	O	CFO	1	S.m	-1	9.12	0	0	110	D
9/24/25 16:14	8/6/25	SUPN	Supernus Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Khattar Jack A.	MD	DO	P,CEO	8	S.dm	-12,589	44.13	-285		2,146	D
9/24/25 16:05	9/22/25	TVTX	Travere Therapeutics, Inc.	CA	Health	Drug	Pharmaceutical Preparations	Reed Elizabeth E	CA	O	GC,GC	1	S.d	-250	25.00	-10		90	D
9/24/25 06:35	9/22/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Benkowitz Michael	MD	O	P,COO	4	S.dm	-34,259	408.45	-84		3	I
9/23/25 21:00	9/19/25	ROIV	Roivant Sciences Ltd.	D0	Health	Drug	Pharmaceutical Preparations	Venker Eric	X0	O	P,Immuno	3	S.dm	-27,849	14.57	-1,911		1,654	D
9/23/25 17:32	9/22/25	XOMA	Xoma Royalty Corp	NV	Health	Drug	Pharmaceutical Preparations	Burns Thomas M.	CA	O	SVP,Fina	1	S.d	-156	35.99	-4		40	D
9/23/25 17:07	9/9/25	CYTK	Cytokinetics Inc		Health	Drug	Pharmaceutical Preparations	Malik Fady Ibraham	CA	O	EVP Rese	6	S.d	-493	41.08	-12		141	D
9/23/25 16:57	9/22/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hughes Steven George	CA	O	Chief Me	5	S.d	-3,814	42.89	-89		39	D
9/23/25 16:33	9/19/25	LVTX	Lava Therapeutics Nv	P7	Health	Drug	Pharmaceutical Preparations	Versant Venture Capital Vi, L.P.	CA	T		2	S.m	-6,571	1.43	-4,588		2,903	M
9/22/25 19:49	7/9/25	ABEO	Abeona Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	O'Malley Brendan M.	OH	O	SVP,GC	2	S	-106	5.84	-18		361	D
9/22/25 19:00	9/22/25	AXSM	Axsome Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Jacobson Mark L.	NY	O	COO	2	S.d	-6,401	114.74	-56	-100	0	D
9/22/25 18:32	9/9/25	PAHC	Phibro Animal Health Corp	DE	Health	Drug	Pharmaceutical Preparations	Bendheim Jack	NJ	DOT	P,CEO	2	S.dm	-1,140	40.51	-28		78	I
9/22/25 17:25	9/19/25	AQST	Aquestive Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Barber Daniel	NJ	DO	P,CEO	1	S	-2	6.00	0	0	1,015	D
9/22/25 17:14	9/19/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Davis Krista	MN	O	SVP,CHRO	2	S	-259	93.61	-3		63	D
9/22/25 16:00	7/24/25	LLY	Eli Lilly & Co	IN	Health	Drug	Pharmaceutical Preparations	Lilly Endowment Inc	IN	T		3	S	-325,010	792.14	-410	0	95,737	D
9/19/25 21:17	9/19/25	APLS	Apellis Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Dunlop A. Sinclair	MA	D		1	S	-714	22.95	-31		223	I
9/19/25 20:46	9/18/25	PGEN	Precigen, Inc.	VA	Health	Drug	Pharmaceutical Preparations	Kirk Randal J	VA	DT		1	S.dm	-18,654	3.73	-5,000		128,722	I
9/19/25 18:23	9/18/25	RARE	Ultragenyx Pharmaceutical Inc.	DE	Health	Drug	Pharmaceutical Preparations	Huizenga Theodore Alan	CA	O	SVP,Chie	2	S	-5	30.43	0	0	50	D
9/19/25 16:49	9/19/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Olian Judy D.	MD	D		1	S	-748	415.43	-2		5	D
9/19/25 16:05	9/4/25	RAPP	Rapport Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ceesay Abraham	MA	DO	CEO	2	S	-2,075	26.34	-79		722	D
9/18/25 21:30	9/16/25	OLMA	Olema Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Harmon Cyrus	CA	D		1	S.m	-205	8.19	-25		861	M
9/18/25 18:16	9/16/25	VSTM	Verastem, Inc.	MA	Health	Drug	Pharmaceutical Preparations	Stuglik Brian M	MA	D		1	S	-6	9.99	-1		102	D
9/18/25 18:14	9/16/25	VSTM	Verastem, Inc.	MA	Health	Drug	Pharmaceutical Preparations	Gagnon Robert E.	MA	D		1	S	-3	9.99	0		42	D
9/18/25 18:11	9/16/25	VSTM	Verastem, Inc.	MA	Health	Drug	Pharmaceutical Preparations	Paterson Dan	MA	DO	P,CEO	2	S	-12	6.76	-2	0	443	D
9/18/25 16:45	7/9/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Oyler John	V8	DO	CEO	2	S	-16,100	289.55	-56	0	53,868	D
9/18/25 16:31	8/21/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Mahon Paul A	MD	O	EVP,GC	6	S.d	-22,050	334.09	-66		37	D
9/18/25 16:06	9/17/25	ESPR	Esperion Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Looker Benjamin	MI	O	GC	2	S	-19	2.52	-8		400	D
9/18/25 16:06	9/17/25	ESPR	Esperion Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Koenig Sheldon L.	MI	DO	P,CEO	1	S	-79	2.79	-28		1,519	D
9/18/25 16:06	9/17/25	ESPR	Esperion Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Halladay Benjamin	MI	O	CFO	2	S	-20	2.81	-7		475	D
9/18/25 16:01	9/16/25	APLS	Apellis Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Watson David O.	MA	O	GC	4	S	-882	25.20	-35		209	D
9/17/25 20:08	9/15/25	APLS	Apellis Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Chopas James George	MA	O	VP,Chief	2	S	-20	27.08	-1		54	D
9/17/25 19:39	9/16/25	MNKD	Mannkind Corp	DE	Health	Drug	Pharmaceutical Preparations	Tross Stuart A	CT	O	Chief Pe	1	S	-251	5.34	-47		1,032	D
9/17/25 18:06	9/16/25	TNGX	Tango Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Third Rock Ventures Iv, L.P.	MA	T		4	S.m	-17,496	7.01	-2,495		15,759	D
9/17/25 17:01	9/15/25	BCAX	Bicara Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Meisner Lara	MA	O	GC	1	S.d	-182	11.49	-16	-100	0	D
9/17/25 16:45	9/15/25	KNSA	Kiniksa Pharmaceuticals International, Plc	X0	Health	Drug	Pharmaceutical Preparations	Tessari Eben	X0	O	COO	6	S.dm	-10,332	34.00	-304		50	D
9/17/25 16:31	8/15/25	NUVL	Nuvalent, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Porter James Richard	MA	DO	P,CEO	3	S.d	-6,393	78.92	-81		249	D
9/17/25 16:30	9/15/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Singh Raman	NC	D		2	S.d	-1,396	26.32	-53		31	D
9/17/25 16:15	9/15/25	RAPP	Rapport Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bredt David	MA	O	Chief Sc	3	S	-452	17.73	-26		435	D
9/17/25 16:03	9/15/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	McCarthy Teresa	CA	O	CHRO	2	S.d	-1,087	43.47	-25		97	D
9/16/25 21:45	9/12/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Dunton Alan W	NJ	D		1	S.d	-131	13.13	-10		40	D
9/16/25 19:36	9/12/25	AXSM	Axsome Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Tabuteau Herriot	NY	DOT	CEO	1	S.dm	-7,362	117.08	-63		7,352	D
9/16/25 18:54	8/13/25	MLYS	Mineralys Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rodman David Malcom	PA	O	Chief Me	3	S.d	-722	21.18	-34		98	D
9/16/25 18:16	7/29/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Accardi Mario Alberto	X0	O	P,Orexin	3	S.d	-442	18.80	-23		208	D
9/16/25 18:06	9/12/25	ARWR	Arrowhead Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hamilton James C	CA	O	Chief Me	3	S.m	-1,025	25.63	-40		262	D
9/16/25 18:00	9/15/25	ACAD	Acadia Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Schneyer Mark C.	CA	O	EVP,CFO	2	S	-637	24.97	-25		43	D
9/16/25 16:56	9/12/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	O'Neil Patrick R.	CA	O	EVP CLO,	3	S.dm	-6,862	60.94	-113		57	D
9/16/25 16:35	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Paulson Richard A.	MA	DO	P,CEO	1	S	-8	6.43	-1		84	D
9/16/25 16:34	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Mano Michael	MA	O	SVP,GC,S	1	S	-2	6.43	0		21	D
9/16/25 16:33	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Poulton Stuart	MA	O	EVP,Chie	2	S	-3	5.77	-1		28	D
9/16/25 16:32	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rangwala Reshma	MA	O	EVP,Chie	1	S	-3	6.43	0		29	D
9/16/25 16:31	9/15/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Cheng Sohanya Roshan	MA	O	EVP,Chie	1	S	-2	6.43	0		36	D
9/16/25 16:30	9/3/25	KPTI	Karyopharm Therapeutics Inc.	DE	Health	Drug	Pharmaceutical Preparations	Abate Kristin	MA	O	Chief Ac	3	S	-1	4.33	0		10	D
9/15/25 19:16	9/12/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Cook Meredith	MN	O	SVP,GC,S	3	S	-101	84.06	-1		79	D
9/15/25 18:37	8/15/25	CNTA	Centessa Pharmaceuticals Plc	X0	Health	Drug	Pharmaceutical Preparations	Hussain Iqbal J	X0	O	GC	4	S.dm	-1,164	20.07	-58		111	D
9/15/25 17:39	9/12/25	SUPN	Supernus Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Mottola Frank	MD	O	SVP,Chie	2	S.d	-852	44.87	-19		15	D
9/15/25 16:47	9/2/25	CYTK	Cytokinetics Inc		Health	Drug	Pharmaceutical Preparations	Blum Robert I	CA	DO	P,CEO	6	S	-1,226	40.85	-30		402	D
9/15/25 16:26	9/12/25	MRSN	Mersana Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Huber Martin H. Jr.	MA	DO	P,CEO	1	S.d	-15	7.31	-2		10	D
9/15/25 16:23	9/12/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Schaeffer Orlov S Nicole	NJ	O	Chief Pe	2	S.d	-12,403	143.36	-87		80	D
9/15/25 16:22	9/12/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Sharoky Melvin Md	NJ	D		3	S	-3,965	132.16	-30		334	M
9/15/25 12:45	9/12/25	GALT	Galectin Therapeutics Inc	NV	Health	Drug	Pharmaceutical Preparations	Callicutt Jack W	GA	O	CFO	1	S.d	-56	6.44	-9		8	D
9/15/25 12:45	9/12/25	GALT	Galectin Therapeutics Inc	NV	Health	Drug	Pharmaceutical Preparations	Lewis Joel	GA	DO	P,CEO	1	S.d	-89	6.36	-14		835	D
9/12/25 21:45	9/12/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Todisco Joseph	NJ	O	CEO	1	S.d	-650	13.00	-50		509	D
9/12/25 20:39	9/2/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Young Jonathan	CA	O	COO	3	S.d	-1,199	46.84	-26		257	D
9/12/25 20:39	9/11/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Yale Catriona	CA	O	Chief De	2	S.d	-558	52.33	-11		91	D
9/12/25 20:38	9/11/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	White William Richard	CA	O	CFO	1	S	-28	43.02	-1		58	D
9/12/25 20:36	9/8/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Rolph Timothy	CA	O	Chief Sc	4	S.d	-1,831	48.11	-38		167	D
9/12/25 20:36	9/10/25	AKRO	Akero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Cheng Andrew	CA	DO	P,CEO	3	S.dm	-4,367	47.57	-92		521	D
9/12/25 20:00	9/11/25	MIRM	Mirum Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Brege Laura	CA	D		1	S.d	-1,265	74.40	-17		16	D
9/12/25 20:00	9/12/25	MIRM	Mirum Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Bjerkholt Eric	CA	O	CFO	2	S.d	-728	41.42	-18		40	D
9/12/25 18:00	9/11/25	VTRS	Viatris Inc	DE	Health	Drug	Pharmaceutical Preparations	Le Goff Corinne	PA	O	Chief Co	1	S	-72	10.25	-7		35	D
9/12/25 17:30	9/11/25	CYRX	Cryoport, Inc.	NV	Health	Drug	Pharmaceutical Preparations	Hariri Robert J	TN	D		2	S.d	-286	9.52	-30		51	D
9/12/25 17:09	9/11/25	XERS	Xeris Biopharma Holdings, Inc.		Health	Drug	Pharmaceutical Preparations	Persky Marla	IL	D		1	S	-120	7.72	-16		148	D
9/12/25 17:09	9/10/25	PMVP	Pmv Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Orbimed Advisors LLC	NY	T		2	S.d	-5,792	3.46	-1,676		13,140	I
9/12/25 16:42	9/11/25	TGTX	Tg Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Lonial Sagar	NC	D		1	S	-672	32.24	-21		94	D
9/12/25 16:38	9/10/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Lee Chan Henry	V8	O	SVP,GC	3	S.d	-6,846	312.07	-22		266	D
9/12/25 16:30	8/7/25	NUVL	Nuvalent, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Pelish Henry E.	MA	O	Chief Sc	3	S.dm	-1,319	78.20	-17		66	D
9/12/25 16:11	9/12/25	RARE	Ultragenyx Pharmaceutical Inc.	DE	Health	Drug	Pharmaceutical Preparations	Parschauer Karah Herdman	CA	O	EVP,GC	1	S	-76	31.17	-2		73	D
9/12/25 16:07	9/11/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Flanagan W. Michael	CA	O	Chief Sc	1	S.d	-779	38.94	-20		80	D
9/11/25 21:45	9/9/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Zelnick Kaufman Beth	NJ	O	GC	1	S.d	-670	13.41	-50		180	D
9/11/25 21:45	9/9/25	CRMD	Cormedix Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hurlburt Elizabeth	NJ	O	COO	1	S.dm	-712	13.18	-54		177	D
9/11/25 21:01	9/9/25	NKTR	Nektar Therapeutics	DE	Health	Drug	Pharmaceutical Preparations	Robin Howard W	CA	DO	P,CEO	4	S.dm	-829	38.44	-22		69	D
9/11/25 20:38	9/10/25	CORT	Corcept Therapeutics Inc	DE	Health	Drug	Pharmaceutical Preparations	Swisher Daniel N Jr	CA	D		3	S.d	-475	71.94	-7	-100	0	D
9/11/25 18:57	9/9/25	LFVN	Lifevantage Corp		Health	Drug	Pharmaceutical Preparations	Beindorff Michael A	UT	D		1	S	-49	11.44	-4		120	M
9/11/25 17:20	9/9/25	DNTH	Dianthus Therapeutics, Inc. /De/	DE	Health	Drug	Pharmaceutical Preparations	Savitz Ryan	NY	O	CFO,CBO	1	S.d	-700	35.00	-20	-100	0	D
9/11/25 17:10	9/9/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Wang Lai	V8	O	Global H	3	S.m	-3,262	326.17	-10		1,746	I
9/11/25 17:05	9/9/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Baroldi Joseph	CA	O	EVP,Chie	3	S.d	-2,705	60.10	-45		35	D
9/11/25 16:05	9/9/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Reitan Colleen F	MA	D		1	S.d	-8,417	467.60	-18		1	D
9/10/25 20:12	9/8/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Patel Anish	CO	O	COO	3	S	-389	19.43	-20		297	I
9/10/25 18:21	9/8/25	ARQT	Arcutis Biotherapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Watanabe Todd	CA	DO	See Rema	2	S.m	-343	15.83	-22		1,135	D
9/10/25 17:50	9/8/25	MIRM	Mirum Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ramasastry Saira	CA	D		1	S.d	0	0.00	-17	-100	0	D
9/10/25 17:39	9/9/25	NAMS	Newamsterdam Pharma Co N.V.	P7	Health	Drug	Pharmaceutical Preparations	Kooij Louise Frederika	P7	O	Chief Ac	3	S.d	-4,533	25.71	-176		15	D
9/10/25 17:00	9/8/25	CPRX	Catalyst Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Elsbernd Brian	FL	O	Chief Co	2	S.dm	-1,596	19.95	-80		271	D
9/10/25 16:31	9/9/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Malcolm Jan	MD	D		1	S	-280	400.29	-1		1	D
9/10/25 16:30	9/10/25	UTHR	United Therapeutics Corp	DE	Health	Drug	Pharmaceutical Preparations	Thompson Tommy G	MD	D		1	S.d	-1,839	403.36	-5		22	D
9/10/25 16:15	9/8/25	RAPP	Rapport Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Gault Cheryl	MA	O	COO	1	S.d	-192	38.33	-5		172	D
9/10/25 16:02	9/8/25	APLS	Apellis Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Sullivan Timothy Eugene	MA	O	CFO	1	S.d	-1,190	27.85	-43		171	M
9/10/25 15:09	9/5/25	CYCC	Cyclacel Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kua Khai Loon	N8	T		1	S	-134	7.01	-19		385	D
9/9/25 21:07	9/9/25	MDGL	Madrigal Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Sibold William John	PA	DO	P,CEO	2	S	-6,291	422.39	-15		110	D
9/9/25 19:02	9/8/25	KALV	Kalvista Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Palleiko Benjamin L	MA	DO	CEO	4	S.d	-836	15.03	-56		395	D
9/9/25 18:37	9/8/25	URGN	Urogen Pharma Ltd.	L3	Health	Drug	Pharmaceutical Preparations	Schoenberg Mark	NJ	O	Chief Me	3	S.d	-292	18.23	-16		158	D
9/9/25 18:32	9/8/25	URGN	Urogen Pharma Ltd.	L3	Health	Drug	Pharmaceutical Preparations	Smith Jason Drew	NJ	O	GC	2	S.d	-173	19.13	-9		43	D
9/9/25 18:30	9/5/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Bennett C Frank	CA	O	EVP,Chie	3	S.dm	-3,099	56.43	-55		93	D
9/9/25 17:53	9/5/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Wilson Troy Edward	CA	D		2	S.d	-5,752	46.18	-125		712	D
9/9/25 17:31	9/5/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Sanders Corazon (Corsee) D.	V8	D		1	S.d	-898	337.00	-3		57	D
9/9/25 16:40	9/5/25	PHAT	Phathom Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Breedlove Robert Charles	NJ	O	Principa	2	S	-20	9.16	-2		55	D
9/9/25 16:31	9/5/25	DYN	Dyne Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Cox John	MA	DO	CEO,P	1	S	-35	13.41	-3		272	D
9/9/25 16:26	9/5/25	AGIO	Agios Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Washburn Theodore James Jr.	MA	O	Principa	1	S	-315	36.87	-9		1	D
9/8/25 20:32	9/4/25	NKTR	Nektar Therapeutics	DE	Health	Drug	Pharmaceutical Preparations	Zalevsky Jonathan	CA	O	Chief R,	3	S.d	-92	31.24	-3		20	D
9/8/25 19:06	9/4/25	AQST	Aquestive Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Jung Cassie	NJ	O	COO	1	S.d	-311	5.00	-62		285	D
9/8/25 18:45	9/8/25	SNDX	Syndax Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Metzger Michael A	NY	DO	CEO	2	S.d	-2,652	16.09	-165		299	D
9/8/25 18:06	9/5/25	BBIO	Bridgebio Pharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	McCormick Frank	CA	D		1	S.d	-3,934	53.16	-74		963	D
9/8/25 18:05	9/4/25	BBIO	Bridgebio Pharma, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kumar Neil	CA	DO	CEO	4	S.m	-12,530	47.08	-266		5,932	I
9/8/25 17:14	9/4/25	ARQT	Arcutis Biotherapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Matsuda Masaru	CA	O	See Rema	2	S	-674	15.88	-42		197	D
9/8/25 17:13	9/5/25	AQST	Aquestive Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Boyd Peter E.	NJ	O	See Rema	1	S	-80	5.30	-15		288	D
9/8/25 16:37	9/4/25	KNSA	Kiniksa Pharmaceuticals International, Plc	X0	Health	Drug	Pharmaceutical Preparations	Moat Ross	X0	O	CHIEF CO	1	S	-124	35.31	-4		9	D
9/8/25 16:37	9/8/25	BHC	Bausch Health Companies Inc.	NJ	Health	Drug	Pharmaceutical Preparations	Carson Seana	NJ	O	EVP,GC	1	S	-98	7.31	-13		500	D
9/8/25 16:06	9/4/25	DYN	Dyne Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Friedl-Naderer Johanna	MA	O	Chief Co	1	S.m	-14	13.29	-1		95	D
9/8/25 16:03	9/4/25	DYN	Dyne Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kerr Douglas	MA	O	Chief Me	1	S.m	-59	13.30	-4		88	D
9/5/25 19:48	9/5/25	RCUS	Arcus Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Azoy Alexander	CA	O	Chief Ac	1	S	-19	11.88	-2		30	D
9/5/25 19:43	9/5/25	AXSM	Axsome Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Saad Mark E	NY	D		1	S.d	-1,142	125.07	-9		10	D
9/5/25 18:56	9/5/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Boyce Sarah	CA	DO	P,CEO	2	S.d	-3,732	49.76	-75		306	D
9/5/25 18:32	9/3/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Mosbrooker Eric	CA	O	Chief Co	2	S.d	-6,073	44.21	-137		55	D
9/5/25 18:00	9/4/25	JNJ	Johnson & Johnson	NJ	Health	Drug	Pharmaceutical Preparations	Taubert Jennifer L	NJ	O	EVP,WWC.	1	S.d	-10,041	177.81	-56		178	D
9/5/25 17:01	9/3/25	ROIV	Roivant Sciences Ltd.	D0	Health	Drug	Pharmaceutical Preparations	Ramaswamy Vivek	DC	T		1	S.m	-22,456	12.65	-1,776		48,866	D
9/5/25 16:05	9/3/25	TVTX	Travere Therapeutics, Inc.	CA	Health	Drug	Pharmaceutical Preparations	Cline Christopher R.	CA	O	CFO	2	S.m	-19	17.97	-1		93	D
9/5/25 16:03	9/4/25	SION	Sionna Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Fitzpatrick Jennifer	MA	O	GC	1	S.d	-237	23.12	-10	-100	0	D
9/4/25 20:41	9/2/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Swayze Eric	CA	O	EVP Rese	1	S	-553	49.67	-11		37	D
9/4/25 20:40	9/2/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Wender Joseph H	CA	D		2	S.m	-3,224	57.58	-56		109	I
9/4/25 20:38	9/2/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Parshall B Lynne	CA	D		2	S	-1,228	49.12	-25		86	D
9/4/25 20:38	9/3/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Monia Brett P	CA	DO	CEO	3	S.d	-12,453	60.04	-207		180	D
9/4/25 20:38	9/3/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Klein Joseph III	CA	D		2	S.d	-3,360	60.00	-56		16	I
9/4/25 20:37	9/2/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Geary Richard S	CA	O	EVP,Chie	2	S	-932	46.61	-20		89	D
9/4/25 20:36	9/3/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Devers Shannon L.	CA	O	EVP,Chie	1	S.d	-193	61.02	-3		16	D
9/4/25 20:28	9/3/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Loscalzo Joseph	CA	D		1	S.d	-962	60.15	-16		36	D
9/4/25 20:28	9/3/25	IONS	Ionis Pharmaceuticals Inc	CA	Health	Drug	Pharmaceutical Preparations	Schneider Eugene	CA	O	EVP,Chf	2	S.d	-1,604	54.92	-29		52	D
9/4/25 19:59	9/2/25	CORT	Corcept Therapeutics Inc	DE	Health	Drug	Pharmaceutical Preparations	Guyer William	CA	O	Chief De	5	S.dm	-4,289	71.49	-60		5	D
9/4/25 19:56	9/2/25	CORT	Corcept Therapeutics Inc	DE	Health	Drug	Pharmaceutical Preparations	Lyon Joseph Douglas	CA	O	See Rema	4	S.dm	-1,051	70.08	-15		10	D
9/4/25 19:54	9/2/25	CORT	Corcept Therapeutics Inc	DE	Health	Drug	Pharmaceutical Preparations	Maduck Sean	CA	O	See Rema	4	S.dm	-4,150	69.17	-60		118	D
9/4/25 19:54	9/2/25	CORT	Corcept Therapeutics Inc	DE	Health	Drug	Pharmaceutical Preparations	Belanoff Joseph K	CA	DO	CEO	3	S	-5,608	69.56	-81		2,901	I
9/4/25 18:41	9/2/25	ARQT	Arcutis Biotherapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Welgus Howard G.	CA	D		3	S.d	-427	14.61	-29		100	D
9/4/25 17:48	9/2/25	JAZZ	Jazz Pharmaceuticals Plc	L2	Health	Drug	Pharmaceutical Preparations	Cozadd Bruce C	L2	D		3	S	-993	124.07	-8		437	D
9/4/25 17:47	9/2/25	LGND	Ligand Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Kozarich John W	FL	D		3	S	-254	136.03	-2		46	D
9/4/25 17:29	9/2/25	ONC	Beone Medicines Ltd.		Health	Drug	Pharmaceutical Preparations	Ball Titus B.	V8	O	Principa	1	S	-40	326.76	0	0	72	D
9/4/25 17:26	9/2/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Smith Michael Alexander	NJ	O	GC	2	S.dm	-3,660	141.03	-26		66	D
9/4/25 17:24	9/2/25	INSM	Insmed Inc	VA	Health	Drug	Pharmaceutical Preparations	Flammer Martina M.D.	NJ	O	Chief Me	2	S.d	-27,896	142.79	-195		83	D
9/4/25 16:50	9/2/25	OCUL	Ocular Therapeutix, Inc	DE	Health	Drug	Pharmaceutical Preparations	Notman Donald	MA	O	See Rema	1	S	-13	12.43	-1	0	309	D
9/4/25 16:44	9/3/25	ANIP	Ani Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Pera Antonio R	MN	D		2	S	-1,179	92.72	-13		30	D
9/4/25 16:30	9/2/25	RYTM	Rhythm Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Shulman Joseph	MA	O	Chief Te	4	S.d	-3,165	96.13	-33		9	D
9/4/25 16:30	9/2/25	CRNX	Crinetics Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Pizzuti Dana	CA	O	Chief Me	3	S.d	-1,263	30.44	-41		96	D
9/4/25 14:58	9/2/25	MTSR	Metsera, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Fmr LLC	MA	TH	See Rema	1	S	-10	36.00	0	0	4,325	I
9/4/25 14:54	8/26/25	NATR	Natures Sunshine Products Inc	UT	Health	Drug	Pharmaceutical Preparations	Yates Bryant J	UT	O	EVP,P,Eu	1	S.m	-162	16.74	-10		97	D
9/3/25 18:53	9/2/25	SYRE	Spyre Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Burrows Scott L	MA	O	CFO	1	S	-300	16.26	-18		98	D
9/3/25 18:46	9/2/25	BMY	Bristol Myers Squibb Co	DE	Health	Drug	Pharmaceutical Preparations	Elkins David V	NJ	O	EVP,CFO	1	S	-2,650	47.33	-56		168	D
9/3/25 18:00	9/2/25	ACAD	Acadia Pharmaceuticals Inc	DE	Health	Drug	Pharmaceutical Preparations	Garofalo Elizabeth A.	CA	D		1	S	-42	25.98	-2		25	D
9/3/25 17:53	9/2/25	STOK	Stoke Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ticho Barry	MA	O	Chief Me	4	S	-271	15.63	-17		24	D
9/3/25 17:51	8/29/25	STOK	Stoke Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kaye Edward M. Md	MA	D		3	S.m	-1,805	22.34	-81		177	D
9/3/25 17:50	8/29/25	STOK	Stoke Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Allan Jonathan	MA	O	GC,Corp	3	S.dm	-681	18.16	-38		24	D
9/3/25 17:16	8/29/25	SION	Sionna Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Ridloff Elena	MA	O	CFO,Head	3	S.m	-1,967	23.14	-85		72	D
9/3/25 16:56	8/29/25	COLL	Collegium Pharmaceutical, Inc	VA	Health	Drug	Pharmaceutical Preparations	Smith Thomas B	MA	O	EVP,Chie	1	S	-672	38.42	-17		70	D
9/3/25 16:56	9/3/25	KNSA	Kiniksa Pharmaceuticals International, Plc	X0	Health	Drug	Pharmaceutical Preparations	Megna Michael R	X0	O	CHIEF AC	2	S.d	-933	33.33	-28		38	D
9/3/25 16:33	9/2/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Moomaw Scott	NC	O	Chief Co	2	S.d	-2,092	27.71	-75		223	D
9/3/25 16:33	9/2/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Schundler Russell	NC	O	GC	2	S.d	-143	16.04	-9		595	D
9/3/25 16:32	8/29/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Krepp Sarah	NC	O	Chief Hu	2	S	-44	15.35	-3		143	D
9/3/25 16:31	9/2/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Kaseta Michael	NC	O	CFO,COO	4	S.d	-1,323	21.08	-63		406	D
9/3/25 16:30	8/29/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Boyle Dana	NC	O	Chief Ac	3	S	-46	18.18	-3		187	D
9/3/25 16:20	9/2/25	AMPH	Amphastar Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Petersen Floyd F.	CA	D		3	S	-38	25.09	-2		78	D
9/3/25 06:04	8/28/25	SPRO	Spero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Mahadevia Ankit	MA	D		1	S	-13	1.97	-7		703	D
9/3/25 06:02	8/28/25	SPRO	Spero Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Keutzer Timothy	MA	O	COO	1	S	-3	1.97	-2	0	740	D
9/2/25 20:30	9/2/25	RNA	Avidity Biosciences, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Gallagher Kathleen P.	CA	O	Chief Pr	1	S	-9	47.42	0	0	50	D
9/2/25 19:46	8/28/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Manning Paul B	VA	D		1	S.m	-18,957	28.26	-671		5,950	I
9/2/25 19:11	9/2/25	AXSM	Axsome Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Jeffs Roger	NY	D		5	S.dm	-13,952	92.61	-151		2,758	D
9/2/25 17:03	8/28/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Adair Jason	NC	O	Chief Bu	3	S.dm	-785	26.56	-30		194	D
9/2/25 17:02	8/28/25	LQDA	Liquidia Corp	DE	Health	Drug	Pharmaceutical Preparations	Saggar Rajeev	NC	O	Chief Me	3	S.d	-670	24.05	-28		271	D
9/2/25 16:34	9/2/25	CYTK	Cytokinetics Inc		Health	Drug	Pharmaceutical Preparations	Harrington Robert Arthur	CA	D		1	S	-105	48.67	-2		20	D
9/2/25 16:10	8/29/25	ALNY	Alnylam Pharmaceuticals, Inc.		Health	Drug	Pharmaceutical Preparations	Tanguler Tolga	MA	O	EVP,Chie	2	S	-2,190	449.78	-5		29	D
8/29/25 20:35	8/27/25	CVKD	Cadrenal Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Szot Matthew K	FL	O	CFO	1	S.m	-28	14.00	-2		31	D
8/29/25 20:34	8/27/25	CVKD	Cadrenal Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Pham Quang X	FL	DOT	CEO,CB	1	S.m	-70	13.99	-5		413	D
8/29/25 17:21	8/28/25	XERS	Xeris Biopharma Holdings, Inc.		Health	Drug	Pharmaceutical Preparations	Sherman Jeffrey W	IL	D		1	S.d	-335	7.92	-42		225	D
8/29/25 17:03	8/27/25	ELVN	Enliven Therapeutics, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Hohl Benjamin	CO	O	CFO	4	S.d	-224	20.85	-11		23	D
8/29/25 16:19	8/27/25	APLS	Apellis Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Francois Cedric	MA	DO	CEO	3	S.dm	-9,565	24.90	-384		1,882	I
8/29/25 16:09	8/27/25	AGIO	Agios Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Scadden David	MA	D		2	S.d	-64	40.00	-2		18	D
8/29/25 16:05	8/27/25	SUPN	Supernus Pharmaceuticals, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Newhall Charles W III	MD	D		3	S	-270	45.01	-6		134	D
8/29/25 16:02	8/27/25	VRTX	Vertex Pharmaceuticals Inc / Ma	MA	Health	Drug	Pharmaceutical Preparations	Bhatia Sangeeta N.	MA	D		1	S	-103	386.69	0		5	D
8/28/25 19:32	8/26/25	QTTB	Q32 Bio Inc.	DE	Health	Drug	Pharmaceutical Preparations	Morrison Jodie Pope	MA	DO	CEO	1	S	-19	1.80	-10		122	D
8/28/25 19:30	8/26/25	ARDX	Ardelyx, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Williams Laura A	MA	O	Chief Pa	2	S.d	-527	6.11	-86		396	D
8/28/25 19:29	8/21/25	ARDX	Ardelyx, Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kelliher Mike	MA	O	Chief Bu	1	S	-32	5.93	-5		277	D
8/28/25 19:28	8/26/25	QTTB	Q32 Bio Inc.	DE	Health	Drug	Pharmaceutical Preparations	Violette Shelia M.	MA	O	Chief Sc	1	S	-5	1.80	-3		95	D
8/28/25 19:20	8/26/25	QTTB	Q32 Bio Inc.	DE	Health	Drug	Pharmaceutical Preparations	Kalowski Lee	MA	O	CFO,P	1	S	-8	1.80	-4		49	D

D	Derivative transaction in filing (usually option exercise)
M	Multiple transactions in filing; earliest reported transaction date and weighted average transaction price
A	Amended filing
E	Error detected in filing

S - Sale	Sale of securities on an exchange or to another person
S - Sale+OE	Sale of securities on an exchange or to another person (after option exercise)
F - Tax	Payment of exercise price or tax liability using portion of securities received from the company
P - Purchase	Purchase of securities on an exchange or from another person

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