9/10/18 16:45  | 9/7/18  | ADAP | Adaptimmune Therapeutics Plc | X0 | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | T |  | P | 5,000 | 1.67 | 0 | 3,000 | 4 | 82,979 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
8/1/18 19:17  | 7/30/18  | LQDA | Liquidia Technologies Inc | DE | Health | MdEq | Surgical & Medical Instrument | Barrett M James | MD | T |  | P.d | 6,000 | 11.00 | 0 | 545 | 28 | 2,485 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
4/23/18 16:45  | 4/23/18  | SURF | Surface Oncology, Inc. | DE | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | T |  | P.d | 2,000 | 15.00 | 0 | 133 | 4 | 3,313 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
3/28/18 17:10  | 3/26/18  | ADAP | Adaptimmune Therapeutics Plc | X0 | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | T |  | P.m | 12,588 | 1.92 | 0 | 6,571 | 9 | 79,979 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
3/27/18 16:50  | 3/27/18  | TCON | Tracon Pharmaceuticals, Inc. | DE | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | T |  | P.d | 1,912 | 2.70 | 0 | 708 | 26 | 3,466 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
3/23/18 18:29  | 3/21/18  | ADAP | Adaptimmune Therapeutics Plc | X0 | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | T |  | P.m | 2,418 | 1.91 | 0 | 1,269 | 2 | 73,408 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
3/6/18 21:10  | 3/2/18  | TSRO | Tesaro, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.m | 6,684 | 57.40 | 0 | 116 | 1 | 9,682 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
12/19/17 08:56  | 12/18/17  | PTI | Proteostasis Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P | 10,000 | 5.00 | 0 | 2,000 | 56 | 5,555 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
10/10/17 16:33  | 10/10/17  | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 9,350 | 17.00 | 0 | 550 | 13 | 4,910 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
7/6/17 17:16  | 7/3/17  | MRSN | Mersana Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 15,000 | 15.00 | 0 | 1,000 | 14 | 8,140 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
6/5/17 16:54  | 6/1/17  | SENS | Senseonics Holdings, Inc. | DE | Electr | LabEq | Industrial Instruments For Me | Barrett M James | MD | DT |  | P | 10,000 | 1.41 | 0 | 7,092 | 46 | 22,558 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
3/28/17 16:21  | 3/27/17  | ADAP | Adaptimmune Therapeutics Plc | X0 | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | T |  | P | 9,009 | 0.7000 | 2 | 12,870 | 22 | 72,139 | I |  | -41 | -36 | 15 | 11 | 9 | -4 | 6 | 7 | 27 | 21 |  |  |  | 
11/29/16 18:03  | 11/29/16  | TCON | Tracon Pharmaceuticals, Inc. | DE | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | T |  | P | 5,000 | 5.75 | 0 | 870 | 46 | 2,758 | I |  | -48 | -12 | -6 | 1 | 9 | -14 | -15 | 0 | 0 | -18 | -30 |  |  | 
10/31/16 16:48  | 10/31/16  | RARX | Ra Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 4,400 | 13.00 | 21 | 338 | 11 | 3,490 | I |  |  |  |  |  |  |  |  | 1 | -1 | 1 | 24 | 78 |  | 
9/15/16 16:32  | 9/14/16  | PTI | Proteostasis Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P | 6,000 | 13.00 | 5 | 462 | 15 | 3,555 | I |  |  | 31 | -37 | 14 | -23 | -18 | -1 | 1 | 5 | 17 | -15 | -6 |  | 
8/2/16 16:33  | 7/29/16  | ILIU | Interleukin Genetics Inc | DE | Health | Diagn | In Vitro & In Vivo Diagnostic | Barrett M James | MD | T |  | P.d | 2,000 | 0.0994 | 0 | 20,121 | 57 | 55,419 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
7/20/16 16:38  | 7/18/16  | ARDX | Ardelyx, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P | 6,667 | 8.73 | 1 | 764 | 10 | 8,753 | I | -40 | -44 | -10 | 21 | 8 | 18 | 5 | 11 | 6 | 8 | 4 | 28 | 43 |  | 
3/23/16 17:16  | 3/23/16  | SENS | Senseonics Holdings, Inc. | DE | Electr | LabEq | Industrial Instruments For Me | Barrett M James | MD | DT |  | P | 4,500 | 2.85 | 0 | 1,579 | 11 | 15,466 | I |  |  |  |  |  | -14 | -18 | -18 | -6 | -1 | 19 | 35 | 39 | -37 | 
3/18/16 17:36  | 3/18/16  | TSRO | Tesaro, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P | 25,000 | 35.19 | 26 | 710 | 8 | 9,565 | I | 18 | -27 | -21 | -15 | 21 | 5 | 1 | 0 | -1 | 6 | -1 | -8 | 121 | 238 | 
2/17/16 19:07  | 2/17/16  | PTI | Proteostasis Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P.d | 7,203 | 8.00 | 6 | 900 | 41 | 3,093 | I |  |  |  |  |  |  |  |  | -2 | 13 | 66 | 119 | 161 | 170 | 
1/14/16 16:26  | 1/13/16  | ARDX | Ardelyx, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P | 5,000 | 10.00 | 5 | 500 | 7 | 7,989 | I |  | -59 | -42 | -51 | -51 | -47 | -43 | -8 | 0 | 3 | -3 | -23 | -18 | 34 | 
1/12/16 17:31  | 1/12/16  | EPZM | Epizyme, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P | 10,000 | 9.00 | 13 | 1,111 | 22 | 6,261 | I | -73 | -42 | -58 | -25 | -37 | -39 | -39 | -12 | -4 | -7 | -10 | 20 | 3 | 17 | 
10/6/15 15:09  | 10/6/15  | MIRN | Mirna Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 6,000 | 7.00 | 3 | 857 | 41 | 2,972 | I |  |  |  |  |  |  |  | 0 | 0 | -8 | -18 | -13 | -41 | -74 | 
6/9/15 16:46  | 6/5/15  | ARDX | Ardelyx, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 20,000 | 10.70 | 3 | 1,869 | 33 | 7,489 | I |  |  | -55 | -3 | 25 | 59 | 34 | -2 | 3 | 16 | 9 | 29 | 30 | -38 | 
2/5/15 15:54  | 2/4/15  | TCON | Tracon Pharmaceuticals, Inc. | DE | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | T |  | P.d | 5,000 | 10.00 | 3 | 500 | 36 | 1,888 | I |  |  |  |  |  |  |  | 0 | -1 | 1 | 87 | 10 | 38 | -21 | 
2/2/15 13:33  | 1/30/15  | ZSAN | Zosano Pharma Corp | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P.d | 258 | 11.00 | 6 | 23 | 1 | 2,159 | I |  |  |  |  |  |  |  | 1 | 0 | -1 | -11 | -16 | -30 | -81 | 
12/29/14 17:09  | 12/23/14  | ILIU | Interleukin Genetics Inc | DE | Health | Diagn | In Vitro & In Vivo Diagnostic | Barrett M James | MD | T |  | P.d | 1,993 | 0.1003 | 0 | 19,869 | 129 | 35,298 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
10/8/14 16:36  | 10/8/14  | DERM | Dermira, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 1,106 | 16.00 | 33 | 69 | 2 | 3,503 | I |  |  |  |  |  |  |  |  | -1 | -6 | 8 | 37 | 4 | 70 | 
8/6/14 16:25  | 8/6/14  | LOXO | Loxo Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P.d | 3,000 | 13.00 | 12 | 231 | 15 | 1,789 | I |  |  |  |  |  |  |  |  | 0 | 1 | 14 | -16 | -8 | 58 | 
7/22/14 17:10  | 7/22/14  | ROKA | Roka Bioscience, Inc. | DE | Electr | LabEq | Laboratory Analytical Instrum | Barrett M James | MD | DT |  | P.d | 4,600 | 12.00 | 8 | 383 | 14 | 3,217 | I |  |  |  |  |  |  |  |  | 0 | -8 | 1 | -25 | -66 | -73 | 
1/15/14 17:15  | 1/15/14  | GLYC | Glycomimetics Inc | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P.d | 8,000 | 8.00 | 13 | 1,000 | 13 | 8,575 | I |  |  |  |  |  |  |  |  | 18 | 6 | 9 | 46 | -15 | -29 | 
11/18/13 07:56  | 11/14/13  | EPZM | Epizyme, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.m | 7,998 | 19.68 | 9 | 407 | 7 | 6,440 | I |  |  |  | -29 | -52 | -53 | -43 | -41 | 3 | 10 | 10 | 59 | 17 | 19 | 
6/7/13 14:56  | 6/5/13  | EPZM | Epizyme, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 6,000 | 15.00 | 20 | 400 | 7 | 6,033 | I |  |  |  |  |  |  |  | -8 | 1 | -11 | 35 | 16 | -8 | -9 | 
4/17/13 21:36  | 4/16/13  | OMTH | Omthera Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 5,000 | 8.00 | 0 | 625 | 12 | 5,833 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
8/2/12 14:21  | 7/31/12  | HPTX | Hyperion Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 5,000 | 10.00 | 0 | 500 | 21 | 2,884 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
7/3/12 12:28  | 7/3/12  | TSRO | Tesaro, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 15,000 | 13.50 | 6 | 1,111 | 11 | 11,499 | I |  |  |  |  |  |  |  |  | -3 | -1 | -4 | 9 | 28 | 132 | 
5/8/12 16:34  | 5/4/12  | SUPN | Supernus Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P.d | 22,000 | 5.00 | 1 | 4,400 | 70 | 10,641 | I |  |  |  |  |  |  |  | 11 | 0 | -2 | -30 | 80 | 91 | -24 | 
3/9/12 15:52  | 3/7/12  | FOLD | Amicus Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P | 5,273 | 5.70 | 1 | 925 | 25 | 4,584 | I | 68 | -5 | 40 | 63 | -14 | -15 | -7 | -2 | 3 | 4 | -13 | -20 | -9 | -44 | 
11/22/11 13:19  | 11/21/11  | CLVS | Clovis Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P.d | 17,112 | 13.00 | 8 | 1,316 | 63 | 3,420 | I |  |  |  |  |  |  |  | 0 | 0 | 2 | 10 | 87 | 50 | -4 | 
10/30/09 17:49  | 10/28/09  | INHX | Inhibitex, Inc. |  | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | DT |  | P.d | 3,000 | 1.28 | 0 | 2,344 | 36 | 8,901 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
3/6/07 20:13  | 3/2/07  | IOMI | Iomai Corp |  | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P.d | 0 | 0.00 | 0 | 1,573 | 32 | 6,417 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
10/27/06 16:56  | 10/25/06  | IOMI | Iomai Corp |  | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P | 5,000 | 4.38 | 0 | 1,142 | 31 | 4,844 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
5/17/06 15:58  | 5/15/06  | NOVC | Novacea Inc | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 7,500 | 6.50 | 0 | 1,154 | 31 | 4,901 | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
4/14/06 15:01  | 4/12/06  | TRGT | Targacept Inc |  | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P | 3,150 | 9.00 | 11 | 350 | New | 350 | S |  |  |  |  |  |  |  |  | -4 | -10 | -13 | -22 | -28 | 5 | 
2/2/06 11:43  | 2/1/06  | IOMI | Iomai Corp |  | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P | 4,674 | 7.00 | 0 | 668 | New | 668 | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
11/29/04 12:30  | 11/10/04  | INHX | Inhibitex Inc |  | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | DT |  | P.ad | 14,225 | 7.34 | 0 | 1,938 | 43 | 6,496 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
11/12/04 14:06  | 11/10/04  | INHX | Inhibitex Inc |  | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | T |  | P.d | 14,225 | 7.34 | 0 | 1,938 | 43 | 6,496 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
10/1/04 14:42  | 9/29/04  | MYOG | Myogen Inc | DE | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | T |  | P.d | 5,579 | 6.50 | 0 | 858 | 26 | 4,204 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
6/7/04 10:31  | 6/3/04  | INHX | Inhibitex Inc |  | Health | BioPrd | Biological Products, (No Diag | Barrett M James | MD | DT |  | P | 7,490 | 7.00 | 0 | 1,070 | New | 1,070 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
11/7/03 19:37  | 11/5/03  | PHRM | Pharmion Corp |  | Health | Drug | Pharmaceutical Preparations | Barrett M James | MD | DT |  | P | 5,600 | 14.00 | 0 | 400 | 10 | 4,341 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  |