| 10/30/25 20:00 | 10/28/25 | JANX | Janux Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Meyer Andrew Hollman | CA | O | Chief Bu | 7 | S.d | -3,985 | 42.70 | 0 | -93 |  | 82 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 19:02 | 10/28/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Watanabe Todd | CA | DO | See Rema | 12 | S.dm | -3,539 | 16.80 | 0 | -211 |  | 1,161 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:09 | 9/9/25 | PAHC | Phibro Animal Health Corp | DE | Health | Drug | Pharmaceutical Preparations | Bendheim Jack | NJ | DOT | P,CEO | 6 | S.dm | -3,855 | 40.56 | 0 | -95 |  | 91 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:06 | 10/30/25 | NRIX | Nurix Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Van Houte Hans | CA | O | CFO | 13 | S.d | -1,564 | 19.08 | 0 | -82 |  | 54 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:02 | 10/30/25 | NRIX | Nurix Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ring Christine | CA | O | GC | 17 | S.d | -1,853 | 21.41 | 0 | -87 |  | 51 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:01 | 10/30/25 | NRIX | Nurix Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hansen Gwenn | CA | O | Chief Sc | 6 | S.d | -370 | 16.59 | 0 | -22 |  | 77 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:00 | 10/28/25 | BGMS | Bio Green Med Solution, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Yap Kim Choy | N8 | T |  | 3 | S | -316 | 2.07 | 0 | -153 |  | 385 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:47 | 10/28/25 | KNSA | Kiniksa Pharmaceuticals International, Plc | X0 | Health | Drug | Pharmaceutical Preparations | Ragosa Mark | X0 | O | CFO | 10 | S.dm | -6,665 | 25.10 | 0 | -266 |  | 31 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:45 | 10/28/25 | TVTX | Travere Therapeutics, Inc. | CA | Health | Drug | Pharmaceutical Preparations | Dube Eric M | CA | DO | CEO | 6 | S.dm | -5,787 | 24.85 | 0 | -233 |  | 431 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:45 | 10/28/25 | TVTX | Travere Therapeutics, Inc. | CA | Health | Drug | Pharmaceutical Preparations | Heerma Peter | CA | O | Chief Co | 6 | S.dm | -414 | 21.75 | 0 | -19 |  | 128 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:44 | 10/28/25 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Shulman Joseph | MA | O | Chief Te | 13 | S.d | -7,027 | 84.66 | 0 | -83 |  | 9 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:37 | 8/21/25 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Mahon Paul A | MD | O | EVP,GC | 18 | S.d | -65,009 | 339.65 | 0 | -191 |  | 37 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:30 | 8/26/24 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Rothblatt Martine A | MD | DO | CHAIRPER | 46 | S.dm | -120,151 | 370.07 | 0 | -325 |  | 647 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:25 | 9/2/25 | CYTK | Cytokinetics Inc |  | Health | Drug | Pharmaceutical Preparations | Blum Robert I | CA | DO | P,CEO | 32 | S.d | -13,082 | 47.25 | 0 | -277 |  | 432 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 08:49 | 10/28/25 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Jaen Juan C. | CA | O | P | 1 | S.m | -2,011 | 20.76 | 0 | -97 |  | 1,459 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 19:22 | 3/27/25 | HOWL | Werewolf Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Evnin Luke | MA | D |  | 2 | S.dm | -289 | 1.61 | 0 | -180 |  | 4,310 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 19:21 | 3/27/25 | HOWL | Werewolf Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mpm Bioventures 2014, L.P. | MA | T |  | 3 | S.dm | -1,366 | 4.23 | 0 | -323 |  | 10,824 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 19:21 | 3/27/25 | HOWL | Werewolf Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Gadicke Ansbert | MA | T |  | 2 | S.dm | -451 | 1.61 | 0 | -280 |  | 6,719 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 17:10 | 10/27/25 | BBIO | Bridgebio Pharma, Inc. | DE | Health | Drug | Pharmaceutical Preparations | McCormick Frank | CA | D |  | 3 | S.d | -8,463 | 48.18 | 0 | -176 |  | 963 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 17:04 | 8/18/25 | SER | Serina Therapeutics, Inc. | AL | Health | Drug | Pharmaceutical Preparations | Moreadith Randall | AL | O | Chief Sc | 14 | S.dm | -706 | 6.03 | 0 | -117 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:31 | 10/27/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Shair Matthew | MA | D |  | 10 | S.m | -7,575 | 97.12 | 0 | -78 |  | 1,660 | M |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:30 | 10/27/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Adair Jason | NC | O | Chief Bu | 19 | S.dm | -1,125 | 21.66 | 0 | -52 |  | 194 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:30 | 10/27/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Boyle Dana | NC | O | Chief Ac | 5 | S | -100 | 20.56 | 0 | -5 |  | 187 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:24 | 10/27/25 | NUVB | Nuvation Bio Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hattersley Gary | NY | O | Chief Sc | 1 | S.d | -502 | 5.02 | 0 | -100 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:02 | 10/27/25 | AGIO | Agios Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Gheuens Sarah | MA | O | Chief Me | 6 | S.d | -1,140 | 38.09 | 0 | -30 |  | 62 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 08:54 | 12/31/24 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Goeltz II Robert C. | CA | O | CFO | 2 | S | -154 | 17.91 | 0 | -9 |  | 92 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 21:05 | 8/9/24 | ANTX | An2 Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ra Capital Management, L.P. | MA | T |  | 2 | S.m | -18,570 | 4.76 | 0 | -3,899 |  | 510 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 19:51 | 10/28/25 | VKTX | Viking Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mancini Marianna | CA | O | COO | 4 | S.d | -3,682 | 44.53 | 0 | -83 |  | 382 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 19:49 | 10/27/25 | VKTX | Viking Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Rowland Charles A Jr | CA | D |  | 1 | S.d | -2,134 | 35.57 | 0 | -60 |  | 30 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 19:48 | 10/28/25 | VKTX | Viking Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Lian Brian | CA | DO | P,CEO | 7 | S.d | -39,902 | 56.50 | 0 | -706 |  | 2,419 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 19:47 | 10/28/25 | VKTX | Viking Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Zante Greg | CA | O | CFO | 5 | S.d | -13,497 | 64.71 | 0 | -209 |  | 187 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 18:00 | 10/24/25 | BGMS | Bio Green Med Solution, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ong Yee Lung | N8 | T |  | 2 | S | -854 | 5.49 | 0 | -156 |  | 269 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 17:00 | 10/24/25 | CVKD | Cadrenal Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Szot Matthew K | FL | O | CFO | 6 | S.m | -328 | 14.03 | 0 | -23 |  | 31 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 17:00 | 10/24/25 | CVKD | Cadrenal Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Pham Quang X | FL | DOT | CEO,CB | 6 | S.m | -312 | 14.04 | 0 | -22 |  | 413 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 16:30 | 10/27/25 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Benkowitz Michael | MD | O | P,COO | 30 | S.dm | -170,607 | 389.73 | 0 | -438 |  | 3 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 16:10 | 10/27/25 | MRSN | Mersana Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bala Mohan | MA | O | SVP,Chie | 5 | S.dm | -37 | 1.49 | 0 | -25 |  | 69 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 19:56 | 7/29/25 | CNTA | Centessa Pharmaceuticals Plc | X0 | Health | Drug | Pharmaceutical Preparations | Accardi Mario Alberto | X0 | O | P,Orexin | 5 | S.d | -852 | 18.32 | 0 | -46 |  | 216 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 17:59 | 10/27/25 | CYTK | Cytokinetics Inc |  | Health | Drug | Pharmaceutical Preparations | Wierenga Wendell | CA | D |  | 1 | S.d | -257 | 58.68 | 0 | -4 |  | 32 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 17:19 | 10/23/25 | SPRY | Ars Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Orbimed Advisors LLC | NY | D |  | 10 | S.dm | -51,570 | 11.98 | 0 | -4,305 |  | 22,582 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 16:23 | 10/24/25 | CRBP | Corbus Pharmaceuticals Holdings, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cohen Yuval | MA | DO | CEO | 3 | S.dm | -3,484 | 35.51 | 0 | -98 |  | 138 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 16:22 | 10/24/25 | CRBP | Corbus Pharmaceuticals Holdings, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Moran Sean F. | MA | O | CFO | 3 | S.dm | -1,109 | 32.80 | 0 | -34 |  | 73 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 16:15 | 10/23/25 | TNGX | Tango Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Third Rock Ventures Iv, L.P. | MA | T |  | 17 | S.m | -49,905 | 8.58 | 0 | -5,815 |  | 18,651 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:18 | 10/22/25 | GALT | Galectin Therapeutics Inc | NV | Health | Drug | Pharmaceutical Preparations | 10X Fund, L.P. | GA | T |  | 1 | S | -247 | 4.94 | 0 | -50 |  | 5,872 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 6/24/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Iwicki Mark T | MA | D |  | 6 | S.d | -376 | 1.78 | 0 | -211 |  | 280 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 10/22/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Reumuth Mary | MA | O | CFO | 5 | S.dm | -86 | 1.88 | 0 | -46 |  | 69 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 10/22/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bazemore Todd | MA | D |  | 5 | S.d | -106 | 1.71 | 0 | -62 |  | 88 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 6/24/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Brazzell Romulus K | MA | O | SEE REMA | 5 | S.d | -118 | 1.86 | 0 | -64 |  | 92 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 10/22/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kharabi Darius | MA | O | CHIEF BU | 5 | S.d | -78 | 2.35 | 0 | -33 |  | 68 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 16:56 | 10/22/25 | RNA | Avidity Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hughes Steven George | CA | O | Chief Me | 8 | S.d | -4,330 | 41.37 | 0 | -105 |  | 82 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 16:30 | 10/23/25 | ALZN | Alzamend Neuro, Inc. | DE | Health | Drug | Pharmaceutical Preparations | McGrath Lynne Fahey | GA | D |  | 1 | S | 0 | 2.30 | 0 | 0 |  | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 16:01 | 10/22/25 | IRON | Disc Medicine, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ai Dmi LLC | NY | T |  | 1 | S | -59,873 | 80.47 | 0 | -744 |  | 2,814 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/23/25 18:00 | 10/21/25 | BGMS | Bio Green Med Solution, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Fitters Diversified Berhad | N8 | T |  | 5 | S | -1,777 | 4.23 | 0 | -420 |  | 557 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/23/25 16:20 | 10/21/25 | APLS | Apellis Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Sullivan Timothy Eugene | MA | O | CFO | 6 | S.d | -1,695 | 28.12 | 0 | -60 |  | 203 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 19:20 | 10/20/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Lyssikatos Joseph P | CO | O | CHIEF SC | 20 | S.m | -4,747 | 23.52 | 0 | -202 |  | 1,105 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 18:57 | 10/20/25 | RANI | Rani Therapeutics Holdings, Inc. | DE | Health | Drug | Pharmaceutical Preparations | South Cone Investments Limited Partnership | F3 | T |  | 2 | S.m | -25,853 | 2.65 | 0 | -9,752 |  | 8,302 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 17:39 | 8/26/25 | SION | Sionna Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | 5 | S.dm | -6,328 | 31.64 | 0 | -200 |  | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 17:09 | 10/20/25 | KNSA | Kiniksa Pharmaceuticals International, Plc | X0 | Health | Drug | Pharmaceutical Preparations | Patel Sanj K | X0 | DO | CB,CEO | 7 | S.dm | -18,285 | 31.35 | 0 | -583 |  | 222 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 17:06 | 10/20/25 | KNSA | Kiniksa Pharmaceuticals International, Plc | X0 | Health | Drug | Pharmaceutical Preparations | Megna Michael R | X0 | O | CHIEF AC | 7 | S.dm | -4,202 | 32.56 | 0 | -129 |  | 38 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 16:32 | 10/20/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Miller Deborah Ann | MA | O | GC | 9 | S.dm | -6,130 | 87.61 | 0 | -70 |  | 49 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/21/25 18:18 | 9/9/25 | CYTK | Cytokinetics Inc |  | Health | Drug | Pharmaceutical Preparations | Malik Fady Ibraham | CA | O | EVP Rese | 36 | S.d | -7,471 | 50.08 | 0 | -149 |  | 141 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/21/25 18:13 | 10/17/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kintz Samuel | CO | DO | P,CEO | 21 | S.m | -4,238 | 22.95 | 0 | -185 |  | 1,253 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/21/25 17:12 | 10/21/25 | SION | Sionna Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Booth Bruce | MA | D |  | 5 | S.m | -22,086 | 31.62 | 0 | -698 |  | 3,615 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/21/25 16:54 | 10/20/25 | CRBP | Corbus Pharmaceuticals Holdings, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Altmeyer Anne | MA | D |  | 2 | S.d | -32 | 12.98 | 0 | -2 |  | 6 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/20/25 20:00 | 9/12/25 | BYSI | Beyondspring Inc. |  | Health | Drug | Pharmaceutical Preparations | Decheng Capital China Life Sciences Usd Fund Iii, L.P. | CA | T |  | 17 | S.m | -2,020 | 2.36 | 0 | -855 |  | 4,488 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/20/25 19:13 | 10/17/25 | JNJ | Johnson & Johnson | NJ | Health | Drug | Pharmaceutical Preparations | Reed John C | NJ | O | EVP,Inno | 2 | S.d | -7,316 | 179.05 | 0 | -41 |  | 11 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/20/25 18:58 | 10/16/25 | LVTX | Lava Therapeutics Nv | P7 | Health | Drug | Pharmaceutical Preparations | Cooperatieve Gilde Healthcare IV U.A. | P7 | T |  | 3 | S.m | -5,141 | 1.48 | 0 | -3,473 |  | 5,294 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/20/25 18:00 | 10/15/25 | BGMS | Bio Green Med Solution, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kua Khai Loon | N8 | T |  | 3 | S.m | -815 | 5.03 | 0 | -162 |  | 385 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 21:00 | 10/15/25 | ROIV | Roivant Sciences Ltd. | D0 | Health | Drug | Pharmaceutical Preparations | Venker Eric | X0 | O | P,Immuno | 18 | S.dm | -92,095 | 13.36 | 0 | -6,893 |  | 1,654 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 17:53 | 10/15/25 | KROS | Keros Therapeutics, Inc. |  | Health | Drug | Pharmaceutical Preparations | Pontifax Management 4 G.P. (2015) Ltd. | L3 | T |  | 1 | S | -84,975 | 17.75 | 0 | -4,787 | -100 | 11 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:41 | 10/15/25 | IRON | Disc Medicine, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bitterman Kevin | MA | D |  | 8 | S.m | -19,663 | 72.70 | 0 | -270 |  | 1,148 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:32 | 8/15/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Porter James Richard | MA | DO | P,CEO | 14 | S.d | -29,729 | 80.72 | 0 | -368 |  | 249 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:31 | 8/7/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Pelish Henry E. | MA | O | Chief Sc | 10 | S.dm | -8,707 | 88.92 | 0 | -98 |  | 66 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:31 | 10/15/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Balcom Alexandra | MA | O | CFO | 13 | S.dm | -16,560 | 85.68 | 0 | -193 |  | 62 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:28 | 10/16/25 | SDGR | Schrodinger, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Dugan Margaret | NY | O | Chief Me | 2 | S | -57 | 19.35 | 0 | -3 |  | 25 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:27 | 10/15/25 | RNA | Avidity Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | McCarthy Teresa | CA | O | CHRO | 12 | S.d | -7,828 | 41.22 | 0 | -190 |  | 105 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:15 | 10/16/25 | APLS | Apellis Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Watson David O. | MA | O | GC | 12 | S | -1,743 | 26.11 | 0 | -67 |  | 228 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:10 | 10/16/25 | PRAX | Praxis Precision Medicines, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Adage Capital Management, L.P. | MA | T |  | 1 | S | -33,198 | 105.76 | 0 | -314 |  | 4,422 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 14:01 | 10/15/25 | AQST | Aquestive Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Jung Cassie | NJ | O | COO | 3 | S.d | -785 | 6.05 | 0 | -130 |  | 285 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 14:01 | 10/15/25 | AQST | Aquestive Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kraus Carl N | NJ | O | Chief Me | 1 | S | -142 | 7.00 | 0 | -20 |  | 282 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 14:00 | 10/15/25 | AQST | Aquestive Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Boyd Peter E. | NJ | O | See Rema | 3 | S | -213 | 6.07 | 0 | -35 |  | 288 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 20:16 | 10/16/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Swayze Eric | CA | O | EVP Rese | 9 | S.adm | -3,247 | 57.08 | 0 | -57 |  | 48 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 20:16 | 9/9/24 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Parshall B Lynne | CA | D |  | 10 | S.d | -3,536 | 54.40 | 0 | -65 |  | 107 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 20:16 | 10/15/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Devers Shannon L. | CA | O | EVP,Chie | 3 | S.dm | -863 | 58.77 | 0 | -15 |  | 17 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 20:15 | 10/14/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Birchler Brian | CA | O | EVP,Corp | 3 | S.dm | -1,920 | 64.04 | 0 | -30 |  | 57 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:41 | 10/15/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cohlhepp Ryan | MA | DO | P,COO | 2 | S.dm | -1,139 | 18.08 | 0 | -63 |  | 203 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:35 | 10/14/25 | KNSA | Kiniksa Pharmaceuticals International, Plc | X0 | Health | Drug | Pharmaceutical Preparations | Tessari Eben | X0 | O | COO | 20 | S.dm | -18,604 | 30.86 | 0 | -603 |  | 120 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:30 | 10/15/25 | RAPP | Rapport Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bredt David | MA | O | Chief Sc | 8 | S | -1,020 | 14.99 | 0 | -68 |  | 469 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:30 | 9/4/25 | RAPP | Rapport Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ceesay Abraham | MA | DO | CEO | 3 | S | -2,357 | 26.28 | 0 | -90 |  | 722 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:21 | 10/7/25 | EBS | Emergent Biosolutions Inc. | DE | Health | Drug | Pharmaceutical Preparations | Glessner Coleen | MD | O | EVP,Qual | 1 | S | -306 | 10.00 | 0 | -31 |  | 144 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:15 | 7/9/25 | ABEO | Abeona Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Seshadri Vishwas | OH | DO | CEO | 5 | S.m | -1,105 | 5.83 | 0 | -190 |  | 1,355 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:13 | 8/15/25 | CNTA | Centessa Pharmaceuticals Plc | X0 | Health | Drug | Pharmaceutical Preparations | Hussain Iqbal J | X0 | O | GC | 12 | S.dm | -3,112 | 17.51 | 0 | -178 |  | 131 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:01 | 10/14/25 | RCKT | Rocket Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Militello John | NJ | O | See Rema | 12 | S.m | -259 | 5.57 | 0 | -46 |  | 67 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 20:12 | 10/10/25 | APLS | Apellis Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Dunlop A. Sinclair | MA | D |  | 5 | S | -4,946 | 29.57 | 0 | -167 |  | 302 | M |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 19:04 | 10/13/25 | MLYS | Mineralys Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Levy Adam Scott | PA | O | CFO,Secr | 7 | S.m | -2,200 | 15.92 | 0 | -138 |  | 248 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 19:04 | 10/13/25 | MLYS | Mineralys Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Congleton Jon | PA | DO | CEO | 7 | S.m | -2,236 | 15.43 | 0 | -145 |  | 927 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 19:04 | 10/15/25 | MLYS | Mineralys Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Rodman David Malcom | PA | O | Chief Me | 11 | S.d | -3,018 | 18.25 | 0 | -165 |  | 141 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 18:47 | 10/15/25 | ALKS | Alkermes Plc. |  | Health | Drug | Pharmaceutical Preparations | Hopkinson Craig C. | MA | O | EVP R,D, | 8 | S.dm | -20,144 | 32.84 | 0 | -613 |  | 99 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 18:31 | 10/10/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Swisher Daniel N Jr | CA | D |  | 14 | S.d | -1,855 | 64.53 | 0 | -29 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 18:00 | 10/13/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mazumdar Claire | MA | DO | CEO | 1 | S.dm | -467 | 18.88 | 0 | -25 |  | 310 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:36 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Schundler Russell | NC | O | GC | 12 | S.d | -846 | 15.18 | 0 | -56 |  | 597 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:34 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Kaseta Michael | NC | O | CFO,COO | 14 | S.d | -2,376 | 17.93 | 0 | -132 |  | 412 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:34 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Moomaw Scott | NC | O | Chief Co | 12 | S.d | -2,531 | 24.31 | 0 | -104 |  | 225 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:33 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Saggar Rajeev | NC | O | Chief Me | 13 | S.d | -1,205 | 18.90 | 0 | -64 |  | 273 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:32 | 10/6/25 | SPRB | Spruce Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Parkman Healthcare Partners LLC | CT | T |  | 2 | S | -10 | 19.14 | 0 | -1 |  | 1 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:31 | 9/2/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Jeffs Roger | NC | DO | CEO | 11 | S.dm | -15,591 | 61.36 | 0 | -254 |  | 2,764 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:30 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Krepp Sarah | NC | O | Chief Hu | 3 | S | -84 | 18.33 | 0 | -5 |  | 143 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 13:24 | 10/15/25 | KROS | Keros Therapeutics, Inc. |  | Health | Drug | Pharmaceutical Preparations | Adar1 Capital Management, LLC | TX | T |  | 1 | S | -95,659 | 17.75 | 0 | -5,389 | -100 | 0 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 20:11 | 10/10/25 | AKRO | Akero Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cheng Andrew | CA | DO | P,CEO | 17 | S.dm | -22,662 | 41.01 | 0 | -553 |  | 716 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 19:49 | 10/13/25 | ANIP | Ani Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Cook Meredith | MN | O | SVP,GC,S | 16 | S | -374 | 67.94 | 0 | -6 |  | 82 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 16:31 | 10/9/25 | VSTM | Verastem, Inc. | MA | Health | Drug | Pharmaceutical Preparations | Bunn Paul A. | MA | D |  | 1 | S | -75 | 9.06 | 0 | -8 |  | 8 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 16:01 | 12/16/24 | PTGX | Protagonist Therapeutics, Inc | DE | Health | Drug | Pharmaceutical Preparations | Waddill William D. | CA | D |  | 7 | S.dm | -2,535 | 53.38 | 0 | -47 |  | 54 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 16:00 | 7/24/25 | LLY | Eli Lilly & Co | IN | Health | Drug | Pharmaceutical Preparations | Lilly Endowment Inc | IN | T |  | 35 | S.e | -2,817,666 | 864.18 | 0 | -3,260 |  | 97,779 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 12:15 | 10/13/25 | RARE | Ultragenyx Pharmaceutical Inc. | DE | Health | Drug | Pharmaceutical Preparations | Horn Howard | CA | O | CFO | 3 | S | -716 | 41.66 | 0 | -17 |  | 106 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 19:17 | 10/10/25 | ZVRA | Zevra Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | McFarlane Neil F. | FL | DO | P,CEO | 2 | S.dm | -938 | 8.43 | 0 | -111 |  | 222 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 17:40 | 9/4/25 | BBIO | Bridgebio Pharma, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kumar Neil | CA | DO | CEO | 13 | S.dm | -52,350 | 38.53 | 0 | -1,359 |  | 6,906 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 17:33 | 10/9/25 | SUPN | Supernus Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Khattar Jack A. | MD | DO | P,CEO | 15 | S.dm | -27,668 | 42.17 | 0 | -656 |  | 2,212 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 17:23 | 10/9/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Raben David | MA | O | Chief Me | 1 | S.d | -406 | 18.45 | 0 | -22 |  | 35 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 17:22 | 10/9/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hyep Ivan | MA | O | CFO | 2 | S.dm | -670 | 18.21 | 0 | -37 |  | 145 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:56 | 10/8/25 | ONC | Beone Medicines Ltd. |  | Health | Drug | Pharmaceutical Preparations | Lee Chan Henry | V8 | O | SVP,GC | 11 | S.d | -12,008 | 310.97 | 0 | -39 |  | 278 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:30 | 10/8/25 | ALZN | Alzamend Neuro, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ault Milton C III | NV | D |  | 11 | S.dm | -2,218 | 2.45 | 0 | -906 |  | 124 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:21 | 10/9/25 | SUPN | Supernus Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Newhall Charles W III | MD | D |  | 5 | S.d | -1,927 | 46.21 | 0 | -42 |  | 134 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:18 | 10/8/25 | AGIO | Agios Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Scadden David | MA | D |  | 5 | S.d | -89 | 40.66 | 0 | -2 |  | 18 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:12 | 10/8/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kaye Edward M. Md | MA | D |  | 11 | S.dm | -4,841 | 24.51 | 0 | -198 |  | 183 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:01 | 10/8/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Anderman Todd | MA | O | GC | 1 | S | -137 | 12.34 | 0 | -11 |  | 88 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 18:58 | 9/8/25 | AKRO | Akero Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Rolph Timothy | CA | O | Chief Sc | 18 | S.dm | -9,328 | 49.43 | 0 | -189 |  | 198 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 17:51 | 10/7/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Guyer William | CA | O | Chief De | 16 | S.dm | -13,730 | 65.38 | 0 | -210 |  | 6 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 17:21 | 10/7/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Patel Anish | CO | O | COO | 12 | S.dm | -3,150 | 22.65 | 0 | -139 |  | 344 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 16:22 | 8/19/25 | HOOK | Hookipa Pharma Inc. | DE | Health | Drug | Pharmaceutical Preparations | Peters Malte | NY | DO | CEO | 2 | S | -48 | 0.8745 | 0 | -54 |  | 80 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 13:37 | 10/8/25 | URGN | Urogen Pharma Ltd. | L3 | Health | Drug | Pharmaceutical Preparations | Degnan Chris | NJ | O | CFO | 1 | S.d | -37 | 16.85 | 0 | -2 |  | 2 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 21:08 | 10/6/25 | AXSM | Axsome Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Tabuteau Herriot | NY | DOT | CEO | 2 | S.dm | -12,780 | 118.04 | 0 | -108 |  | 7,352 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 19:48 | 10/1/25 | RMTI | Rockwell Medical, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hunter Heather | MI | O | SVP,COO | 1 | S | -3 | 1.19 | 0 | -3 |  | 135 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 19:08 | 10/6/25 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Jarrett Jennifer | CA | O | COO | 1 | S.dm | -750 | 14.92 | 0 | -50 |  | 214 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 18:37 | 10/6/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | O'Neil Patrick R. | CA | O | EVP CLO, | 11 | S.adm | -14,432 | 61.64 | 0 | -234 |  | 64 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 18:36 | 10/6/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Monia Brett P | CA | DO | CEO | 11 | S.ad | -17,851 | 51.30 | 0 | -348 |  | 220 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 18:36 | 10/6/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Baroldi Joseph | CA | O | EVP,Chie | 7 | S.d | -4,094 | 58.50 | 0 | -70 |  | 35 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 17:37 | 10/6/25 | ORIC | Oric Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Piscitelli Dominic | CA | O | CFO | 7 | S.dm | -850 | 10.65 | 0 | -80 |  | 107 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 17:35 | 10/6/25 | ORIC | Oric Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Chacko Jacob | CA | DO | P,CEO | 4 | S.dm | -3,069 | 11.17 | 0 | -275 |  | 779 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 16:16 | 10/7/25 | CARM | Carisma Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Klichinsky Michael | PA | O | Chief Sc | 2 | S.dm | -139 | 0.2565 | 0 | -541 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 16:10 | 8/5/25 | AIMD | Ainos, Inc. | TX | Health | Drug | Pharmaceutical Preparations | Taiwan Carbon Nano Technology Corp | F5 | T |  | 6 | S.m | -167 | 1.94 | 0 | -86 |  | 5,471 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/7/25 16:26 | 10/3/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Allan Jonathan | MA | O | GC,Corp | 7 | S.dm | -1,277 | 17.01 | 0 | -75 |  | 35 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/7/25 16:11 | 10/3/25 | RNA | Avidity Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mosbrooker Eric | CA | O | Chief Co | 3 | S.d | -6,370 | 44.26 | 0 | -144 |  | 55 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 17:13 | 10/2/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Kaiser Peter | MA | O | Chief De | 5 | S | -211 | 9.79 | 0 | -22 |  | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 17:10 | 10/2/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Heier Jeffrey S. | MA | O | Chief Sc | 5 | S | -222 | 9.83 | 0 | -23 |  | 269 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Lee Kevin | X0 | DO | CEO | 6 | S.dm | -437 | 12.42 | 0 | -35 |  | 492 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Skynner Michael | X0 | O | CTO | 6 | S.dm | -143 | 12.34 | 0 | -12 |  | 124 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Milnes Alistair | X0 | O | COO | 6 | S.dm | -169 | 12.19 | 0 | -14 |  | 100 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Hannay Michael Charles Ferguson | X0 | O | CHIEF PR | 6 | S.dm | -57 | 11.97 | 0 | -5 |  | 55 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Young Alethia | X0 | O | CFO | 4 | S.d | -27 | 11.73 | 0 | -2 |  | 46 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Thompson Travis Alvin | X0 | O | Chief Ac | 7 | S.dm | -238 | 19.68 | 0 | -12 |  | 32 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Swanton Robert Charles | X0 | D |  | 1 | S | -1 | 8.55 | 0 | 0 |  | 15 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 15:15 | 5/19/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Edwards Larry Todd | CA | O | See Rema | 4 | S | -260 | 14.56 | 0 | -18 |  | 183 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 21:58 | 7/8/25 | ELTP | Elite Pharmaceuticals Inc /Nv/ | NJ | Health | Drug | Pharmaceutical Preparations | Plassche Douglas | NJ | O | EVP Oper | 3 | S.m | -1,177 | 0.5517 | 0 | -2,134 |  | 3,500 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 21:27 | 2/3/25 | JAZZ | Jazz Pharmaceuticals Plc | L2 | Health | Drug | Pharmaceutical Preparations | Cozadd Bruce C | L2 | D |  | 12 | S.m | -3,876 | 129.21 | 0 | -30 |  | 464 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 18:15 | 10/1/25 | ARWR | Arrowhead Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hamilton James C | CA | O | Chief Me | 5 | S.m | -2,374 | 25.60 | 0 | -93 |  | 272 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:24 | 10/1/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Belanoff Joseph K | CA | DO | CEO | 9 | S.dm | -18,904 | 78.45 | 0 | -241 |  | 3,019 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:17 | 10/1/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Lyon Joseph Douglas | CA | O | See Rema | 14 | S.dm | -23,838 | 92.97 | 0 | -256 |  | 10 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:15 | 10/1/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Maduck Sean | CA | O | See Rema | 12 | S.dm | -23,957 | 79.86 | 0 | -300 |  | 118 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:14 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Poulton Jeffrey V. | MA | O | EVP,CFO | 7 | S.d | -4,298 | 346.38 | 0 | -12 |  | 54 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:14 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Greenstreet Yvonne | MA | DO | CEO | 11 | S.dm | -38,057 | 303.03 | 0 | -126 |  | 99 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:14 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Tanguler Tolga | MA | O | EVP,Chie | 7 | S.d | -3,804 | 368.12 | 0 | -10 |  | 29 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:13 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Fitzgerald Kevin Joseph | MA | O | CSO,EVP, | 8 | S.dm | -10,057 | 283.98 | 0 | -35 |  | 26 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:12 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Garg Pushkal | MA | O | EVP Chie | 10 | S.dm | -24,828 | 298.04 | 0 | -83 |  | 25 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:01 | 10/1/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Welgus Howard G. | CA | D |  | 16 | S.d | -2,057 | 12.91 | 0 | -159 |  | 205 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:56 | 9/3/25 | KPTI | Karyopharm Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Abate Kristin | MA | O | Chief Ac | 5 | S | -7 | 5.85 | 0 | -1 |  | 10 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:45 | 10/1/25 | LGND | Ligand Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Kozarich John W | FL | D |  | 4 | S | -338 | 144.72 | 0 | -2 |  | 46 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:41 | 9/2/25 | CRNX | Crinetics Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Pizzuti Dana | CA | O | Chief Me | 10 | S.d | -4,399 | 41.02 | 0 | -107 |  | 96 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:30 | 9/2/25 | AKRO | Akero Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Young Jonathan | CA | O | COO | 19 | S.d | -8,985 | 37.22 | 0 | -241 |  | 311 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:25 | 10/1/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ticho Barry | MA | O | Chief Me | 16 | S.dm | -1,820 | 12.89 | 0 | -141 |  | 61 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:20 | 10/2/25 | ZLAB | Zai Lab Ltd | E9 | Health | Drug | Pharmaceutical Preparations | Chen Yajing | MA | O | CFO | 11 | S.d | -869 | 31.57 | 0 | -28 |  | 27 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:07 | 10/2/25 | VRTX | Vertex Pharmaceuticals Inc / Ma | MA | Health | Drug | Pharmaceutical Preparations | Biller Jonathan | MA | O | EVP,GC | 4 | S | -3,074 | 453.26 | 0 | -7 |  | 18 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 19:36 | 10/1/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Wender Joseph H | CA | D |  | 3 | S.m | -4,325 | 59.41 | 0 | -73 |  | 109 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 19:24 | 10/1/25 | TERN | Terns Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kuriakose Emil | CA | O | Chief Me | 4 | S | -39 | 5.40 | 0 | -7 |  | 54 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 17:04 | 10/1/25 | AMPH | Amphastar Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Petersen Floyd F. | CA | D |  | 9 | S.d | -258 | 34.36 | 0 | -8 |  | 78 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:47 | 9/30/25 | ONC | Beigene, Ltd. |  | Health | Drug | Pharmaceutical Preparations | Baker Bros. Advisors LP | NY | D |  | 3 | S.m | -385,792 | 154.30 | 0 | -2,500 |  | 9,438 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Klee Justin B. | MA | DO | Co-CEO | 6 | S | -651 | 6.92 | 0 | -94 |  | 3,355 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mazzariello Gina | MA | O | GC | 7 | S.m | -466 | 7.03 | 0 | -66 |  | 188 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Frates James M | MA | O | CFO | 2 | S | -192 | 8.97 | 0 | -21 |  | 318 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cohen Joshua B | MA | DO | Co-CEO | 6 | S | -649 | 6.91 | 0 | -94 |  | 3,355 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bedrosian Camille L | MA | O | Chief Me | 4 | S | -285 | 6.90 | 0 | -41 |  | 194 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 20:14 | 8/25/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Noci Darlene | MA | O | Chief De | 14 | S.dm | -7,044 | 77.40 | 0 | -91 |  | 48 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 19:17 | 10/1/25 | XENE | Xenon Pharmaceuticals Inc. | A1 | Health | Drug | Pharmaceutical Preparations | Mortimer Ian | A1 | DO | P,CEO,IN | 2 | S.dm | -3,218 | 40.23 | 0 | -80 |  | 46 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 17:22 | 9/29/25 | MLTX | Moonlake Immunotherapeutics | E9 | Health | Drug | Pharmaceutical Preparations | Chen Bihua | MA | H | Former 1 | 1 | S.m | -46,868 | 7.21 | 0 | -6,500 |  | 1,994 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 17:16 | 12/9/24 | PRGO | Perrigo Co Plc | L2 | Health | Drug | Pharmaceutical Preparations | Kindler Jeffrey B | MI | D |  | 2 | S.m | -1,102 | 5.74 | 0 | -192 |  | 351 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:57 | 6/16/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Meisner Lara | MA | O | GC | 4 | S.d | -1,867 | 12.91 | 0 | -145 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:55 | 9/30/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Geary Richard S | CA | O | EVP,Chie | 8 | S.dm | -5,237 | 57.26 | 0 | -91 |  | 99 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:46 | 9/29/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hohl Benjamin | CO | O | CFO | 26 | S.dm | -2,094 | 23.58 | 0 | -89 |  | 23 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:30 | 7/9/25 | ABEO | Abeona Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | O'Malley Brendan M. | OH | O | SVP,GC | 4 | S | -227 | 5.98 | 0 | -38 |  | 378 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:30 | 7/22/25 | ABEO | Abeona Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Vazzano Joseph Walter | OH | O | CFO | 5 | S | -438 | 6.37 | 0 | -69 |  | 491 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:24 | 10/1/25 | RMTI | Rockwell Medical, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Chole Timothy | MI | O | SVP,CCO | 6 | S | -17 | 1.26 | 0 | -13 |  | 128 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:23 | 10/1/25 | RMTI | Rockwell Medical, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Neri Jesse | MI | O | SVP,CFO | 4 | S | -3 | 0.9828 | 0 | -4 |  | 127 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:22 | 10/1/25 | RMTI | Rockwell Medical, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Strobeck Mark | MI | DO | P,CEO | 6 | S | -39 | 1.23 | 0 | -32 |  | 338 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:00 | 9/16/24 | ANAB | Anaptysbio, Inc | DE | Health | Drug | Pharmaceutical Preparations | Loumeau Eric J | CA | O | GC | 2 | S.dm | -731 | 35.27 | 0 | -21 |  | 9 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 18:59 | 9/29/25 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Azoy Alexander | CA | O | Chief Ac | 4 | S | -79 | 13.23 | 0 | -6 |  | 30 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 17:56 | 9/26/25 | AGIO | Agios Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Jones Cecilia | MA | O | CFO | 4 | S.d | -399 | 38.98 | 0 | -10 |  | 34 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 17:44 | 9/30/25 | PGEN | Precigen, Inc. | VA | Health | Drug | Pharmaceutical Preparations | Kirk Randal J | VA | DT |  | 2 | S.dm | -24,824 | 3.65 | 0 | -6,810 |  | 128,722 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 16:42 | 9/26/25 | CRNX | Crinetics Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Struthers Richard Scott | CA | DO | P,CEO | 3 | S | -1,349 | 43.04 | 0 | -31 |  | 1,298 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 16:41 | 9/26/25 | CRNX | Crinetics Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Fust Matthew K | CA | D |  | 1 | S.d | -716 | 44.75 | 0 | -16 |  | 23 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/29/25 19:30 | 9/29/25 | KURA | Kura Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Powl Brian T. | CA | O | Chief Co | 2 | S | -92 | 8.78 | 0 | -10 |  | 100 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/29/25 19:30 | 9/29/25 | KURA | Kura Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bair Teresa Brophy | CA | O | GC | 3 | S | -145 | 8.24 | 0 | -18 |  | 148 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/29/25 19:30 | 9/29/25 | KURA | Kura Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ford Kathleen | CA | O | COO | 4 | S | -94 | 8.72 | 0 | -11 |  | 63 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  |