| 10/28/25 21:05 | 10/24/25 | SION | Health | Drug | Pharmaceutical Preparations | Ra Capital Management, L.P. | MA | DT |  | S.m | -14,763 | 39.51 | 0 | -374 | -64 | 209 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 17:39 | 10/21/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | S.d | -3,619 | 36.26 | 0 | -100 | -15 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 17:39 | 10/21/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | M.d | 610 | 6.11 | 0 | 100 | 22 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/21/25 17:12 | 10/21/25 | SION | Health | Drug | Pharmaceutical Preparations | Booth Bruce | MA | D |  | S | -3,042 | 34.22 | 0 | -89 | -3 | 2,996 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/20/25 21:39 | 10/16/25 | SION | Health | Drug | Pharmaceutical Preparations | Booth Bruce | MA | D |  | S.m | -9,251 | 32.30 | 0 | -286 | -8 | 3,084 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 17:11 | 10/15/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | S.dm | -788 | 31.28 | 0 | -25 | -4 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 17:11 | 10/15/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | M.dm | 154 | 6.11 | 0 | 25 | 5 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 18:33 | 10/10/25 | SION | Health | Drug | Pharmaceutical Preparations | Booth Bruce | MA | D |  | S.m | -5,940 | 30.47 | 0 | -195 | -5 | 3,371 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/7/25 17:00 | 10/3/25 | SION | Health | Drug | Pharmaceutical Preparations | Booth Bruce | MA | D |  | S.m | -1,486 | 29.99 | 0 | -50 | -1 | 3,566 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 18:04 | 9/29/25 | SION | Health | Drug | Pharmaceutical Preparations | Booth Bruce | MA | D |  | S.m | -2,367 | 30.08 | 0 | -79 | -2 | 3,615 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 16:09 | 9/26/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | S.dm | -728 | 29.11 | 0 | -25 | -4 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 16:09 | 9/26/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | M.dm | 153 | 6.11 | 0 | 25 | 5 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/5/25 16:03 | 9/4/25 | SION | Health | Drug | Pharmaceutical Preparations | Fitzpatrick Jennifer | MA | O | GC | M.d | 63 | 6.11 | 0 | 10 |  | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/5/25 16:03 | 9/4/25 | SION | Health | Drug | Pharmaceutical Preparations | Fitzpatrick Jennifer | MA | O | GC | S.d | -237 | 23.12 | 0 | -10 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/3/25 17:16 | 8/29/25 | SION | Health | Drug | Pharmaceutical Preparations | Ridloff Elena | MA | O | CFO,Head | S.m | -240 | 25.09 | 0 | -10 | -20 | 39 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/28/25 17:40 | 8/26/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | S.dm | -624 | 24.97 | 0 | -25 | -4 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/28/25 17:40 | 8/26/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | M.dm | 153 | 6.11 | 0 | 25 | 5 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/28/25 17:40 | 8/26/25 | SION | Health | Drug | Pharmaceutical Preparations | Ridloff Elena | MA | O | CFO,Head | S.m | -602 | 25.70 | 0 | -23 | -33 | 48 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/21/25 16:05 | 8/20/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | S.d | -569 | 22.75 | 0 | -25 | -4 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/21/25 16:05 | 8/20/25 | SION | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | M.d | 153 | 6.11 | 0 | 25 | 5 | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/21/25 16:04 | 8/19/25 | SION | Health | Drug | Pharmaceutical Preparations | Ridloff Elena | MA | O | CFO,Head | S.m | -1,124 | 21.62 | 0 | -52 | -42 | 72 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 7/1/25 17:03 | 6/27/25 | SION | Health | Drug | Pharmaceutical Preparations | Tpg Gp A, LLC | TX | T |  | P | 950 | 15.84 | 0 | 60 | 1 | 6,745 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 2/12/25 17:21 | 2/10/25 | SION | Health | Drug | Pharmaceutical Preparations | Tpg Gp A, LLC | TX | T |  | P.d | 20,250 | 18.00 | 0 | 1,125 | 20 | 6,685 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 2/10/25 17:04 | 2/10/25 | SION | Health | Drug | Pharmaceutical Preparations | Ra Capital Management, L.P. | MA | DT |  | P.d | 20,250 | 18.00 | 0 | 1,125 | 94 | 2,324 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 2/10/25 16:28 | 2/10/25 | SION | Health | Drug | Pharmaceutical Preparations | Orbimed Advisors LLC | NY | D |  | P.d | 9,900 | 18.00 | 0 | 550 | 17 | 3,705 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 2/10/25 16:05 | 2/10/25 | SION | Health | Drug | Pharmaceutical Preparations | Thompson Peter A. | MA | D |  | P.d | 9,900 | 18.00 | 0 | 550 | 17 | 3,705 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 2/10/25 16:05 | 2/10/25 | SION | Health | Drug | Pharmaceutical Preparations | Booth Bruce | MA | D |  | P.d | 1,080 | 18.00 | 0 | 60 | 2 | 3,694 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 2/10/25 16:05 | 2/10/25 | SION | Health | Drug | Pharmaceutical Preparations | Atlas Venture Fund Xi, L.P. | MA | T |  | P.d | 1,080 | 18.00 | 0 | 60 | 2 | 3,694 | M |  |  |  |  |  |  |  |  |  |  |  |  |  |  |