| 6/23/25 16:53 | 6/18/25 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | MA | D |  | M.d | 0 | 0.00 | 0 | 4 | 133 | 7 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 3/25/25 16:30 | 3/21/25 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | M.d | 8 | 1.43 | 0 | 5 | 3 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 3/25/25 16:30 | 3/21/25 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | S.d | -35 | 6.58 | 0 | -5 | -2 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/19/24 16:30 | 9/17/24 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | MA | D |  | M.d | 684 | 21.54 | 0 | 32 |  | 3 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/19/24 16:30 | 9/17/24 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | MA | D |  | S.d | -1,664 | 52.40 | 0 | -32 | -91 | 3 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/11/24 16:30 | 9/9/24 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | MA | D |  | M.d | 497 | 13.34 | 0 | 37 |  | 3 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/11/24 16:30 | 9/9/24 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | MA | D |  | S.d | -1,879 | 50.45 | 0 | -37 | -93 | 3 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/9/24 17:00 | 9/6/24 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | M.dm | 9 | 1.43 | 0 | 6 | 3 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/9/24 17:00 | 9/6/24 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | S.dm | -18 | 3.03 | 0 | -6 | -3 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/5/24 16:54 | 9/3/24 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | M.dm | 79 | 1.43 | 0 | 55 | 35 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/5/24 16:54 | 9/3/24 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | S.dm | -170 | 3.09 | 0 | -55 | -21 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/28/24 16:30 | 8/26/24 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | MA | D |  | M.d | 270 | 18.63 | 0 | 15 |  | 3 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/28/24 16:30 | 8/26/24 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | MA | D |  | S.d | -726 | 50.01 | 0 | -15 | -83 | 3 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 6/25/24 16:30 | 6/21/24 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | MA | D |  | M.d | 0 | 0.00 | 0 | 3 | New | 3 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 5/22/24 16:30 | 5/20/24 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | M.d | 55 | 2.19 | 0 | 25 | 13 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 5/22/24 16:30 | 5/20/24 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | S.d | -72 | 2.86 | 0 | -25 | -11 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 5/14/24 16:51 | 5/10/24 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | M.d | 10 | 2.19 | 0 | 5 | 2 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 5/14/24 16:51 | 5/10/24 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | S.d | -13 | 2.90 | 0 | -5 | -2 | 213 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 5/13/19 17:01 | 5/9/19 | TRVI | Trevi Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DOT | See Rema | P.d | 113 | 10.00 | 0 | 11 | 6 | 206 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 4/28/10 15:51 | 4/28/10 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | NY | DO | P,CEO | M.d | 39 | 1.56 | 0 | 25 | 69 | 61 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 11/12/09 15:46 | 11/11/09 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | DO | P,CEO | P | 16 | 2.14 | 0 | 8 | 30 | 32 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 12/6/05 16:36 | 12/2/05 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | P,COO | M.d | 96 | 5.41 | 0 | 18 |  | 6 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 12/6/05 16:36 | 12/2/05 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | P,COO | S.d | -356 | 18.02 | 0 | -20 | -77 | 6 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/5/05 14:38 | 10/3/05 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | M.d | 3 | 5.41 | 0 | 1 | 7 | 8 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/5/05 14:38 | 10/3/05 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | S.d | -9 | 18.00 | 0 | -1 | -6 | 8 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/8/05 10:48 | 9/7/05 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | M.d | 100 | 7.57 | 0 | 13 |  | 8 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/8/05 10:48 | 9/7/05 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | S.d | -211 | 15.98 | 0 | -13 | -63 | 8 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/24/05 15:27 | 8/22/05 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | M.d | 47 | 7.57 | 0 | 6 | 379 | 8 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 8/24/05 15:27 | 8/22/05 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | S.d | -79 | 12.76 | 0 | -6 | -44 | 8 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 3/24/05 16:04 | 3/24/05 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | M.d | 11 | 5.41 | 0 | 2 | 34 | 8 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 2/23/04 10:01 | 2/23/04 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | M.d | 11 | 5.41 | 0 | 2 | 62 | 5 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 12/4/03 14:42 | 12/2/03 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | M | 11 | 5.41 | 0 | 2 | 211 | 3 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/15/03 14:01 | 9/11/03 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | M | 80 | 6.22 | 0 | 13 |  | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/15/03 14:01 | 9/11/03 | PPCO | Penwest Pharmaceuticals Co | WA | Health | Drug | Pharmaceutical Preparations | Good Jennifer L | CT | O | CFO | S | -271 | 20.93 | 0 | -13 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  |