| 10/30/25 20:00 | 10/28/25 | JANX | Janux Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Meyer Andrew Hollman | CA | O | Chief Bu | 1 | S.d | -501 | 30.06 | 0 | -17 |  | 82 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 19:02 | 10/28/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Watanabe Todd | CA | DO | See Rema | 4 | S.m | -2,229 | 20.89 | 0 | -107 |  | 1,135 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:09 | 9/9/25 | PAHC | Phibro Animal Health Corp | DE | Health | Drug | Pharmaceutical Preparations | Bendheim Jack | NJ | DOT | P,CEO | 6 | S.dm | -3,855 | 40.56 | 0 | -95 |  | 91 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:06 | 10/30/25 | NRIX | Nurix Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Van Houte Hans | CA | O | CFO | 1 | S.d | -40 | 12.80 | 0 | -3 |  | 44 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:02 | 10/30/25 | NRIX | Nurix Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ring Christine | CA | O | GC | 1 | S.d | -47 | 12.80 | 0 | -4 |  | 51 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:01 | 10/30/25 | NRIX | Nurix Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hansen Gwenn | CA | O | Chief Sc | 1 | S.d | -52 | 12.80 | 0 | -4 |  | 77 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 18:00 | 10/28/25 | BGMS | Bio Green Med Solution, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Yap Kim Choy | N8 | T |  | 3 | S | -316 | 2.07 | 0 | -153 |  | 385 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:47 | 10/28/25 | KNSA | Kiniksa Pharmaceuticals International, Plc | X0 | Health | Drug | Pharmaceutical Preparations | Ragosa Mark | X0 | O | CFO | 2 | S.d | -625 | 32.93 | 0 | -19 |  | 31 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:45 | 10/28/25 | TVTX | Travere Therapeutics, Inc. | CA | Health | Drug | Pharmaceutical Preparations | Dube Eric M | CA | DO | CEO | 1 | S.dm | -3,638 | 30.32 | 0 | -120 |  | 419 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:45 | 10/28/25 | TVTX | Travere Therapeutics, Inc. | CA | Health | Drug | Pharmaceutical Preparations | Heerma Peter | CA | O | Chief Co | 1 | S | -80 | 30.00 | 0 | -3 |  | 125 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:44 | 10/28/25 | RYTM | Rhythm Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Shulman Joseph | MA | O | Chief Te | 5 | S.d | -4,486 | 106.29 | 0 | -42 |  | 9 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:37 | 8/21/25 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Mahon Paul A | MD | O | EVP,GC | 7 | S.d | -29,904 | 388.37 | 0 | -77 |  | 37 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:30 | 10/27/25 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Rothblatt Martine A | MD | DO | CHAIRPER | 19 | S.dm | -62,670 | 423.44 | 0 | -148 |  | 644 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 16:25 | 9/2/25 | CYTK | Cytokinetics Inc |  | Health | Drug | Pharmaceutical Preparations | Blum Robert I | CA | DO | P,CEO | 6 | S | -1,574 | 52.48 | 0 | -30 |  | 387 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/30/25 08:49 | 10/28/25 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Jaen Juan C. | CA | O | P | 1 | S.m | -2,011 | 20.76 | 0 | -97 |  | 1,459 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 19:22 | 10/27/25 | HOWL | Werewolf Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Evnin Luke | MA | D |  | 1 | S.m | -286 | 1.62 | 0 | -177 |  | 4,133 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 19:21 | 10/27/25 | HOWL | Werewolf Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mpm Bioventures 2014, L.P. | MA | T |  | 1 | S.m | -446 | 1.62 | 0 | -276 |  | 6,443 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 19:21 | 10/27/25 | HOWL | Werewolf Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Gadicke Ansbert | MA | T |  | 1 | S.m | -446 | 1.62 | 0 | -276 |  | 6,443 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 17:10 | 10/27/25 | BBIO | Bridgebio Pharma, Inc. | DE | Health | Drug | Pharmaceutical Preparations | McCormick Frank | CA | D |  | 2 | S.d | -4,040 | 53.41 | 0 | -76 |  | 963 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 17:04 | 8/18/25 | SER | Serina Therapeutics, Inc. | AL | Health | Drug | Pharmaceutical Preparations | Moreadith Randall | AL | O | Chief Sc | 8 | S.dm | -498 | 6.20 | 0 | -80 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:31 | 10/27/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Shair Matthew | MA | D |  | 1 | S.m | -6,015 | 100.26 | 0 | -60 |  | 1,586 | M |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:30 | 10/27/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Adair Jason | NC | O | Chief Bu | 3 | S.dm | -841 | 27.23 | 0 | -31 |  | 176 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:30 | 10/27/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Boyle Dana | NC | O | Chief Ac | 3 | S | -62 | 23.85 | 0 | -3 |  | 187 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:24 | 10/27/25 | NUVB | Nuvation Bio Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hattersley Gary | NY | O | Chief Sc | 1 | S.d | -502 | 5.02 | 0 | -100 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 16:02 | 10/27/25 | AGIO | Agios Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Gheuens Sarah | MA | O | Chief Me | 1 | S.d | -145 | 43.92 | 0 | -3 |  | 62 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/29/25 08:54 | 10/28/25 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Goeltz II Robert C. | CA | O | CFO | 1 | S | -100 | 20.00 | 0 | -5 |  | 92 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 21:05 | 10/24/25 | SION | Sionna Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ra Capital Management, L.P. | MA | DT |  | 1 | S.m | -14,763 | 39.51 | 0 | -374 |  | 209 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 19:51 | 10/28/25 | VKTX | Viking Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mancini Marianna | CA | O | COO | 1 | S | -216 | 35.00 | 0 | -6 |  | 382 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 19:49 | 10/27/25 | VKTX | Viking Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Rowland Charles A Jr | CA | D |  | 1 | S.d | -2,134 | 35.57 | 0 | -60 |  | 30 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 19:48 | 10/28/25 | VKTX | Viking Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Lian Brian | CA | DO | P,CEO | 1 | S | -1,365 | 35.01 | 0 | -39 |  | 2,419 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 19:47 | 10/28/25 | VKTX | Viking Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Zante Greg | CA | O | CFO | 1 | S | -216 | 35.00 | 0 | -6 |  | 174 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 18:00 | 10/24/25 | BGMS | Bio Green Med Solution, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ong Yee Lung | N8 | T |  | 2 | S | -854 | 5.49 | 0 | -156 |  | 269 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 17:00 | 10/24/25 | CVKD | Cadrenal Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Szot Matthew K | FL | O | CFO | 6 | S.m | -328 | 14.03 | 0 | -23 |  | 31 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 17:00 | 10/24/25 | CVKD | Cadrenal Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Pham Quang X | FL | DOT | CEO,CB | 6 | S.m | -312 | 14.04 | 0 | -22 |  | 413 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 16:30 | 10/27/25 | UTHR | United Therapeutics Corp | DE | Health | Drug | Pharmaceutical Preparations | Benkowitz Michael | MD | O | P,COO | 9 | S.dm | -82,798 | 421.63 | 0 | -196 |  | 3 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/28/25 16:10 | 10/27/25 | MRSN | Mersana Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bala Mohan | MA | O | SVP,Chie | 1 | S.d | -1 | 9.90 | 0 | 0 |  | 3 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 19:56 | 10/27/25 | CNTA | Centessa Pharmaceuticals Plc | X0 | Health | Drug | Pharmaceutical Preparations | Accardi Mario Alberto | X0 | O | P,Orexin | 3 | S.d | -515 | 22.22 | 0 | -23 |  | 206 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 17:59 | 10/27/25 | CYTK | Cytokinetics Inc |  | Health | Drug | Pharmaceutical Preparations | Wierenga Wendell | CA | D |  | 1 | S.d | -257 | 58.68 | 0 | -4 |  | 32 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 17:19 | 10/23/25 | PMVP | Pmv Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Orbimed Advisors LLC | NY | T |  | 2 | S | -2,420 | 1.61 | 0 | -1,500 |  | 5,975 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 16:23 | 10/24/25 | CRBP | Corbus Pharmaceuticals Holdings, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cohen Yuval | MA | DO | CEO | 1 | S.dm | -471 | 17.05 | 0 | -28 |  | 138 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 16:22 | 10/24/25 | CRBP | Corbus Pharmaceuticals Holdings, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Moran Sean F. | MA | O | CFO | 1 | S.d | -221 | 17.02 | 0 | -13 |  | 73 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/27/25 16:15 | 10/23/25 | TNGX | Tango Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Third Rock Ventures Iv, L.P. | MA | T |  | 6 | S.m | -26,351 | 7.59 | 0 | -3,473 |  | 15,759 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:18 | 10/22/25 | GALT | Galectin Therapeutics Inc | NV | Health | Drug | Pharmaceutical Preparations | 10X Fund, L.P. | GA | T |  | 1 | S | -247 | 4.94 | 0 | -50 |  | 5,872 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 10/23/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Iwicki Mark T | MA | D |  | 1 | S | -125 | 0.8100 | 0 | -155 |  | 104 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 10/22/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Reumuth Mary | MA | O | CFO | 1 | S.m | -28 | 0.8297 | 0 | -33 |  | 29 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 10/22/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bazemore Todd | MA | D |  | 1 | S | -40 | 0.8300 | 0 | -48 |  | 36 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 10/22/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Brazzell Romulus K | MA | O | SEE REMA | 1 | S | -39 | 0.8300 | 0 | -47 |  | 36 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 20:00 | 10/22/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kharabi Darius | MA | O | CHIEF BU | 1 | S | -17 | 0.8300 | 0 | -21 |  | 42 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 16:56 | 10/22/25 | RNA | Avidity Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hughes Steven George | CA | O | Chief Me | 6 | S.d | -3,919 | 43.00 | 0 | -91 |  | 39 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 16:30 | 10/23/25 | ALZN | Alzamend Neuro, Inc. | DE | Health | Drug | Pharmaceutical Preparations | McGrath Lynne Fahey | GA | D |  | 1 | S | 0 | 2.30 | 0 | 0 |  | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/24/25 16:01 | 10/22/25 | IRON | Disc Medicine, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ai Dmi LLC | NY | T |  | 1 | S | -59,873 | 80.47 | 0 | -744 |  | 2,814 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/23/25 18:00 | 10/21/25 | BGMS | Bio Green Med Solution, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Fitters Diversified Berhad | N8 | T |  | 5 | S | -1,777 | 4.23 | 0 | -420 |  | 557 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/23/25 16:20 | 10/21/25 | APLS | Apellis Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Sullivan Timothy Eugene | MA | O | CFO | 2 | S.d | -1,470 | 27.89 | 0 | -53 |  | 171 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 19:20 | 10/20/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Lyssikatos Joseph P | CO | O | CHIEF SC | 5 | S.m | -771 | 20.56 | 0 | -38 |  | 940 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 18:57 | 10/20/25 | RANI | Rani Therapeutics Holdings, Inc. | CA | Health | Drug | Pharmaceutical Preparations | South Cone Investments Limited Partnership | F3 | T |  | 1 | S.m | -15,711 | 2.65 | 0 | -5,923 |  | 2,379 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 17:39 | 8/26/25 | SION | Sionna Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cloonan Michael | MA | DO | P,CEO | 5 | S.dm | -6,328 | 31.64 | 0 | -200 |  | 547 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 17:09 | 10/20/25 | KNSA | Kiniksa Pharmaceuticals International, Plc | X0 | Health | Drug | Pharmaceutical Preparations | Patel Sanj K | X0 | DO | CB,CEO | 1 | S.dm | -10,024 | 38.86 | 0 | -258 |  | 222 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 17:06 | 10/20/25 | KNSA | Kiniksa Pharmaceuticals International, Plc | X0 | Health | Drug | Pharmaceutical Preparations | Megna Michael R | X0 | O | CHIEF AC | 3 | S.d | -2,896 | 36.90 | 0 | -78 |  | 38 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/22/25 16:32 | 10/20/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Miller Deborah Ann | MA | O | GC | 2 | S.dm | -3,015 | 91.36 | 0 | -33 |  | 49 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/21/25 18:18 | 9/9/25 | CYTK | Cytokinetics Inc |  | Health | Drug | Pharmaceutical Preparations | Malik Fady Ibraham | CA | O | EVP Rese | 6 | S.d | -594 | 49.08 | 0 | -12 |  | 141 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/21/25 18:13 | 10/17/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kintz Samuel | CO | DO | P,CEO | 6 | S.m | -763 | 20.35 | 0 | -38 |  | 929 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/21/25 17:12 | 10/21/25 | SION | Sionna Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Booth Bruce | MA | D |  | 5 | S.m | -22,086 | 31.62 | 0 | -698 |  | 3,615 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/21/25 16:54 | 10/20/25 | CRBP | Corbus Pharmaceuticals Holdings, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Altmeyer Anne | MA | D |  | 1 | S.d | -22 | 20.50 | 0 | -1 |  | 6 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/20/25 20:00 | 9/12/25 | BYSI | Beyondspring Inc. |  | Health | Drug | Pharmaceutical Preparations | Decheng Capital China Life Sciences Usd Fund Iii, L.P. | CA | T |  | 17 | S.m | -2,020 | 2.36 | 0 | -855 |  | 4,488 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/20/25 19:13 | 10/17/25 | JNJ | Johnson & Johnson | NJ | Health | Drug | Pharmaceutical Preparations | Reed John C | NJ | O | EVP,Inno | 1 | S.d | -4,186 | 192.71 | 0 | -22 |  | 11 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/20/25 18:58 | 10/16/25 | LVTX | Lava Therapeutics Nv | P7 | Health | Drug | Pharmaceutical Preparations | Cooperatieve Gilde Healthcare IV U.A. | P7 | T |  | 3 | S.m | -5,141 | 1.48 | 0 | -3,473 |  | 5,294 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/20/25 18:00 | 10/15/25 | BGMS | Bio Green Med Solution, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kua Khai Loon | N8 | T |  | 3 | S.m | -815 | 5.03 | 0 | -162 |  | 385 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 21:00 | 10/15/25 | ROIV | Roivant Sciences Ltd. | D0 | Health | Drug | Pharmaceutical Preparations | Venker Eric | X0 | O | P,Immuno | 5 | S.dm | -53,993 | 15.64 | 0 | -3,453 |  | 1,654 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 17:53 | 10/15/25 | KROS | Keros Therapeutics, Inc. |  | Health | Drug | Pharmaceutical Preparations | Pontifax Management 4 G.P. (2015) Ltd. | L3 | T |  | 1 | S | -84,975 | 17.75 | 0 | -4,787 | -100 | 11 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:41 | 10/15/25 | IRON | Disc Medicine, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bitterman Kevin | MA | D |  | 5 | S.m | -16,488 | 75.48 | 0 | -218 |  | 1,097 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:32 | 8/15/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Porter James Richard | MA | DO | P,CEO | 3 | S.d | -6,618 | 81.71 | 0 | -81 |  | 249 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:31 | 8/7/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Pelish Henry E. | MA | O | Chief Sc | 4 | S.dm | -2,879 | 85.94 | 0 | -34 |  | 66 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:31 | 10/15/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Balcom Alexandra | MA | O | CFO | 4 | S.dm | -7,694 | 86.19 | 0 | -89 |  | 62 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:28 | 10/16/25 | SDGR | Schrodinger, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Dugan Margaret | NY | O | Chief Me | 1 | S | -29 | 21.07 | 0 | -1 |  | 25 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:27 | 10/15/25 | RNA | Avidity Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | McCarthy Teresa | CA | O | CHRO | 3 | S.d | -2,090 | 46.44 | 0 | -45 |  | 97 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:15 | 10/16/25 | APLS | Apellis Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Watson David O. | MA | O | GC | 4 | S | -910 | 26.01 | 0 | -35 |  | 204 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 16:10 | 10/16/25 | PRAX | Praxis Precision Medicines, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Adage Capital Management, L.P. | MA | T |  | 1 | S | -33,198 | 105.76 | 0 | -314 |  | 4,422 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 14:01 | 10/15/25 | AQST | Aquestive Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Jung Cassie | NJ | O | COO | 2 | S.d | -785 | 6.05 | 0 | -130 |  | 285 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 14:01 | 10/15/25 | AQST | Aquestive Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kraus Carl N | NJ | O | Chief Me | 1 | S | -142 | 7.00 | 0 | -20 |  | 282 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/17/25 14:00 | 10/15/25 | AQST | Aquestive Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Boyd Peter E. | NJ | O | See Rema | 3 | S | -213 | 6.07 | 0 | -35 |  | 288 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 20:16 | 10/16/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Swayze Eric | CA | O | EVP Rese | 4 | S.dm | -2,823 | 62.54 | 0 | -45 |  | 37 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 20:16 | 10/15/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Parshall B Lynne | CA | D |  | 3 | S | -1,587 | 52.89 | 0 | -30 |  | 86 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 20:16 | 10/15/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Devers Shannon L. | CA | O | EVP,Chie | 2 | S.dm | -724 | 69.41 | 0 | -10 |  | 17 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 20:15 | 10/14/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Birchler Brian | CA | O | EVP,Corp | 1 | S.dm | -1,724 | 72.13 | 0 | -24 |  | 57 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:41 | 10/15/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cohlhepp Ryan | MA | DO | P,COO | 2 | S.dm | -1,139 | 18.08 | 0 | -63 |  | 203 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:35 | 10/14/25 | KNSA | Kiniksa Pharmaceuticals International, Plc | X0 | Health | Drug | Pharmaceutical Preparations | Tessari Eben | X0 | O | COO | 7 | S.dm | -11,865 | 34.97 | 0 | -339 |  | 50 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:30 | 10/15/25 | RAPP | Rapport Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bredt David | MA | O | Chief Sc | 3 | S | -552 | 21.66 | 0 | -26 |  | 427 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:30 | 9/4/25 | RAPP | Rapport Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ceesay Abraham | MA | DO | CEO | 3 | S | -2,357 | 26.28 | 0 | -90 |  | 722 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:21 | 10/7/25 | EBS | Emergent Biosolutions Inc. | DE | Health | Drug | Pharmaceutical Preparations | Glessner Coleen | MD | O | EVP,Qual | 1 | S | -306 | 10.00 | 0 | -31 |  | 144 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:15 | 10/16/25 | ABEO | Abeona Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Seshadri Vishwas | OH | DO | CEO | 2 | S.m | -236 | 5.31 | 0 | -45 |  | 1,190 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:13 | 8/15/25 | CNTA | Centessa Pharmaceuticals Plc | X0 | Health | Drug | Pharmaceutical Preparations | Hussain Iqbal J | X0 | O | GC | 4 | S.dm | -1,209 | 20.85 | 0 | -58 |  | 111 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/16/25 16:01 | 10/14/25 | RCKT | Rocket Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Militello John | NJ | O | See Rema | 3 | S.m | -139 | 3.76 | 0 | -37 |  | 67 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 20:12 | 10/10/25 | APLS | Apellis Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Dunlop A. Sinclair | MA | D |  | 3 | S | -2,153 | 23.08 | 0 | -93 |  | 223 | M |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 19:04 | 10/13/25 | MLYS | Mineralys Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Levy Adam Scott | PA | O | CFO,Secr | 1 | S | -452 | 42.01 | 0 | -11 |  | 117 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 19:04 | 10/13/25 | MLYS | Mineralys Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Congleton Jon | PA | DO | CEO | 1 | S | -644 | 42.67 | 0 | -15 |  | 831 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 19:04 | 10/15/25 | MLYS | Mineralys Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Rodman David Malcom | PA | O | Chief Me | 3 | S.d | -1,002 | 30.28 | 0 | -33 |  | 93 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 18:47 | 10/15/25 | ALKS | Alkermes Plc. |  | Health | Drug | Pharmaceutical Preparations | Hopkinson Craig C. | MA | O | EVP R,D, | 1 | S.d | -284 | 31.53 | 0 | -9 |  | 74 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 18:31 | 10/10/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Swisher Daniel N Jr | CA | D |  | 3 | S.d | -511 | 77.43 | 0 | -7 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 18:00 | 10/13/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mazumdar Claire | MA | DO | CEO | 1 | S.dm | -467 | 18.88 | 0 | -25 |  | 310 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:36 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Schundler Russell | NC | O | GC | 2 | S.d | -214 | 24.08 | 0 | -9 |  | 595 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:34 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Kaseta Michael | NC | O | CFO,COO | 4 | S.d | -1,429 | 22.77 | 0 | -63 |  | 376 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:34 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Moomaw Scott | NC | O | Chief Co | 2 | S.d | -2,138 | 28.29 | 0 | -76 |  | 155 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:33 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Saggar Rajeev | NC | O | Chief Me | 2 | S.d | -682 | 26.92 | 0 | -25 |  | 250 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:32 | 10/6/25 | SPRB | Spruce Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Parkman Healthcare Partners LLC | CT | T |  | 2 | S | -10 | 19.14 | 0 | -1 |  | 1 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:31 | 9/2/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Jeffs Roger | NC | DO | CEO | 4 | S.dm | -13,848 | 106.18 | 0 | -130 |  | 2,752 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 16:30 | 10/13/25 | LQDA | Liquidia Corp | DE | Health | Drug | Pharmaceutical Preparations | Krepp Sarah | NC | O | Chief Hu | 2 | S | -46 | 24.03 | 0 | -2 |  | 143 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/15/25 13:24 | 10/15/25 | KROS | Keros Therapeutics, Inc. |  | Health | Drug | Pharmaceutical Preparations | Adar1 Capital Management, LLC | TX | T |  | 1 | S | -95,659 | 17.75 | 0 | -5,389 | -100 | 0 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 20:11 | 10/10/25 | AKRO | Akero Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cheng Andrew | CA | DO | P,CEO | 3 | S.dm | -4,452 | 48.49 | 0 | -92 |  | 526 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 19:49 | 10/13/25 | ANIP | Ani Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Cook Meredith | MN | O | SVP,GC,S | 3 | S | -111 | 92.46 | 0 | -1 |  | 76 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 16:31 | 10/9/25 | VSTM | Verastem, Inc. | MA | Health | Drug | Pharmaceutical Preparations | Bunn Paul A. | MA | D |  | 1 | S | -75 | 9.06 | 0 | -8 |  | 8 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 16:01 | 10/10/25 | PTGX | Protagonist Therapeutics, Inc | DE | Health | Drug | Pharmaceutical Preparations | Waddill William D. | CA | D |  | 3 | S.d | -1,473 | 73.67 | 0 | -20 |  | 9 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 16:00 | 10/10/25 | LLY | Eli Lilly & Co | IN | Health | Drug | Pharmaceutical Preparations | Lilly Endowment Inc | IN | T |  | 12 | S | -982,956 | 816.64 | 0 | -1,204 |  | 95,630 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/14/25 12:15 | 10/13/25 | RARE | Ultragenyx Pharmaceutical Inc. | DE | Health | Drug | Pharmaceutical Preparations | Horn Howard | CA | O | CFO | 1 | S | -250 | 31.51 | 0 | -8 |  | 98 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 19:17 | 10/10/25 | ZVRA | Zevra Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | McFarlane Neil F. | FL | DO | P,CEO | 1 | S.d | -211 | 10.82 | 0 | -20 |  | 222 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 17:40 | 9/4/25 | BBIO | Bridgebio Pharma, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kumar Neil | CA | DO | CEO | 4 | S.m | -13,503 | 50.73 | 0 | -266 |  | 5,857 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 17:33 | 10/9/25 | SUPN | Supernus Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Khattar Jack A. | MD | DO | P,CEO | 13 | S.dm | -18,547 | 45.67 | 0 | -406 |  | 2,212 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 17:23 | 10/9/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Raben David | MA | O | Chief Me | 1 | S.d | -406 | 18.45 | 0 | -22 |  | 35 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 17:22 | 10/9/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hyep Ivan | MA | O | CFO | 2 | S.dm | -670 | 18.21 | 0 | -37 |  | 145 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:56 | 10/8/25 | ONC | Beone Medicines Ltd. |  | Health | Drug | Pharmaceutical Preparations | Lee Chan Henry | V8 | O | SVP,GC | 3 | S.d | -10,305 | 325.19 | 0 | -32 |  | 252 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:30 | 10/8/25 | ALZN | Alzamend Neuro, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ault Milton C III | NV | D |  | 7 | S.dm | -1,584 | 2.40 | 0 | -661 |  | 124 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:21 | 10/9/25 | SUPN | Supernus Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Newhall Charles W III | MD | D |  | 4 | S | -1,539 | 49.65 | 0 | -31 |  | 134 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:18 | 10/8/25 | AGIO | Agios Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Scadden David | MA | D |  | 3 | S.d | -24 | 40.33 | 0 | -1 |  | 18 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:12 | 10/8/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kaye Edward M. Md | MA | D |  | 7 | S.dm | -4,394 | 27.18 | 0 | -162 |  | 177 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/10/25 16:01 | 10/8/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Anderman Todd | MA | O | GC | 1 | S | -137 | 12.34 | 0 | -11 |  | 88 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 18:58 | 9/8/25 | AKRO | Akero Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Rolph Timothy | CA | O | Chief Sc | 4 | S.d | -1,768 | 46.47 | 0 | -38 |  | 167 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 17:51 | 10/7/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Guyer William | CA | O | Chief De | 4 | S.d | -5,722 | 76.27 | 0 | -75 |  | 5 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 17:21 | 10/7/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Patel Anish | CO | O | COO | 3 | S | -391 | 19.53 | 0 | -20 |  | 290 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 16:22 | 8/19/25 | HOOK | Hookipa Pharma Inc. | DE | Health | Drug | Pharmaceutical Preparations | Peters Malte | NY | DO | CEO | 1 | S | -21 | 0.8217 | 0 | -25 |  | 54 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/9/25 13:37 | 10/8/25 | URGN | Urogen Pharma Ltd. | L3 | Health | Drug | Pharmaceutical Preparations | Degnan Chris | NJ | O | CFO | 1 | S.d | -37 | 16.85 | 0 | -2 |  | 2 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 21:08 | 10/6/25 | AXSM | Axsome Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Tabuteau Herriot | NY | DOT | CEO | 2 | S.dm | -12,780 | 118.04 | 0 | -108 |  | 7,352 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 19:48 | 10/1/25 | RMTI | Rockwell Medical, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hunter Heather | MI | O | SVP,COO | 1 | S | -3 | 1.19 | 0 | -3 |  | 135 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 19:08 | 10/6/25 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Jarrett Jennifer | CA | O | COO | 1 | S.dm | -750 | 14.92 | 0 | -50 |  | 214 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 18:37 | 10/6/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | O'Neil Patrick R. | CA | O | EVP CLO, | 6 | S.dm | -13,812 | 63.94 | 0 | -216 |  | 57 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 18:36 | 10/6/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Monia Brett P | CA | DO | CEO | 2 | S.d | -12,325 | 60.34 | 0 | -204 |  | 180 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 18:36 | 10/6/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Baroldi Joseph | CA | O | EVP,Chie | 5 | S.d | -3,837 | 62.27 | 0 | -62 |  | 35 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 17:37 | 10/6/25 | ORIC | Oric Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Piscitelli Dominic | CA | O | CFO | 1 | S.d | -160 | 14.52 | 0 | -11 |  | 48 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 17:35 | 10/6/25 | ORIC | Oric Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Chacko Jacob | CA | DO | P,CEO | 3 | S.m | -2,865 | 11.46 | 0 | -250 |  | 656 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 16:16 | 10/7/25 | CARM | Carisma Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Klichinsky Michael | PA | O | Chief Sc | 2 | S.dm | -139 | 0.2565 | 0 | -541 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/8/25 16:10 | 8/5/25 | AIMD | Ainos, Inc. | TX | Health | Drug | Pharmaceutical Preparations | Taiwan Carbon Nano Technology Corp | F5 | T |  | 4 | S.m | -128 | 2.98 | 0 | -43 |  | 1,049 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/7/25 16:26 | 10/3/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Allan Jonathan | MA | O | GC,Corp | 4 | S.dm | -932 | 19.61 | 0 | -48 |  | 24 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/7/25 16:11 | 10/3/25 | RNA | Avidity Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mosbrooker Eric | CA | O | Chief Co | 3 | S.d | -6,370 | 44.26 | 0 | -144 |  | 55 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 17:13 | 10/2/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Kaiser Peter | MA | O | Chief De | 2 | S | -143 | 11.27 | 0 | -13 |  | 204 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 17:10 | 10/2/25 | OCUL | Ocular Therapeutix, Inc | DE | Health | Drug | Pharmaceutical Preparations | Heier Jeffrey S. | MA | O | Chief Sc | 2 | S | -153 | 11.27 | 0 | -14 |  | 260 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Lee Kevin | X0 | DO | CEO | 1 | S.m | -46 | 8.41 | 0 | -5 |  | 475 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Skynner Michael | X0 | O | CTO | 1 | S.m | -15 | 8.41 | 0 | -2 |  | 118 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Milnes Alistair | X0 | O | COO | 1 | S.m | -18 | 8.40 | 0 | -2 |  | 93 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Hannay Michael Charles Ferguson | X0 | O | CHIEF PR | 1 | S.m | -6 | 8.40 | 0 | -1 |  | 53 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Young Alethia | X0 | O | CFO | 1 | S | -4 | 8.51 | 0 | 0 |  | 45 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Thompson Travis Alvin | X0 | O | Chief Ac | 1 | S.m | -3 | 8.40 | 0 | 0 |  | 31 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 16:45 | 10/2/25 | BCYC | Bicycle Therapeutics Plc | X0 | Health | Drug | Pharmaceutical Preparations | Swanton Robert Charles | X0 | D |  | 1 | S | -1 | 8.55 | 0 | 0 |  | 15 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/6/25 15:15 | 10/2/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Edwards Larry Todd | CA | O | See Rema | 1 | S | -90 | 20.04 | 0 | -5 |  | 179 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 21:58 | 10/2/25 | ELTP | Elite Pharmaceuticals Inc /Nv/ | NJ | Health | Drug | Pharmaceutical Preparations | Plassche Douglas | NJ | O | EVP Oper | 1 | S | -499 | 0.6240 | 0 | -800 |  | 3,500 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 21:27 | 9/2/25 | JAZZ | Jazz Pharmaceuticals Plc | L2 | Health | Drug | Pharmaceutical Preparations | Cozadd Bruce C | L2 | D |  | 3 | S.m | -1,638 | 131.08 | 0 | -13 |  | 436 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 18:15 | 10/1/25 | ARWR | Arrowhead Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hamilton James C | CA | O | Chief Me | 4 | S.m | -1,725 | 28.75 | 0 | -60 |  | 262 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:24 | 10/1/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Belanoff Joseph K | CA | DO | CEO | 3 | S | -8,965 | 74.71 | 0 | -120 |  | 2,861 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:17 | 10/1/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Lyon Joseph Douglas | CA | O | See Rema | 3 | S.d | -1,168 | 73.83 | 0 | -16 |  | 10 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:15 | 10/1/25 | CORT | Corcept Therapeutics Inc | DE | Health | Drug | Pharmaceutical Preparations | Maduck Sean | CA | O | See Rema | 3 | S.d | -5,484 | 73.12 | 0 | -75 |  | 118 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:14 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Poulton Jeffrey V. | MA | O | EVP,CFO | 2 | S | -2,758 | 452.50 | 0 | -6 |  | 54 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:14 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Greenstreet Yvonne | MA | DO | CEO | 2 | S | -7,197 | 452.58 | 0 | -16 |  | 66 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:14 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Tanguler Tolga | MA | O | EVP,Chie | 3 | S | -2,826 | 450.28 | 0 | -6 |  | 29 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:13 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Fitzgerald Kevin Joseph | MA | O | CSO,EVP, | 2 | S | -1,736 | 452.49 | 0 | -4 |  | 26 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:12 | 10/2/25 | ALNY | Alnylam Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Garg Pushkal | MA | O | EVP Chie | 2 | S.m | -3,992 | 453.10 | 0 | -9 |  | 21 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 17:01 | 10/1/25 | ARQT | Arcutis Biotherapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Welgus Howard G. | CA | D |  | 3 | S.d | -489 | 16.29 | 0 | -30 |  | 100 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:56 | 9/3/25 | KPTI | Karyopharm Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Abate Kristin | MA | O | Chief Ac | 3 | S | -3 | 6.32 | 0 | 0 |  | 10 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:45 | 10/1/25 | LGND | Ligand Pharmaceuticals Inc | DE | Health | Drug | Pharmaceutical Preparations | Kozarich John W | FL | D |  | 3 | S | -221 | 157.86 | 0 | -1 |  | 46 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:41 | 9/2/25 | CRNX | Crinetics Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Pizzuti Dana | CA | O | Chief Me | 4 | S.d | -1,472 | 31.66 | 0 | -46 |  | 96 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:30 | 9/2/25 | AKRO | Akero Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Young Jonathan | CA | O | COO | 4 | S.d | -1,796 | 47.14 | 0 | -38 |  | 257 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:25 | 10/1/25 | STOK | Stoke Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ticho Barry | MA | O | Chief Me | 4 | S | -345 | 18.98 | 0 | -18 |  | 24 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:20 | 10/2/25 | ZLAB | Zai Lab Ltd | E9 | Health | Drug | Pharmaceutical Preparations | Chen Yajing | MA | O | CFO | 3 | S.d | -206 | 34.37 | 0 | -6 |  | 17 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/3/25 16:07 | 10/2/25 | VRTX | Vertex Pharmaceuticals Inc / Ma | MA | Health | Drug | Pharmaceutical Preparations | Biller Jonathan | MA | O | EVP,GC | 1 | S | -281 | 404.21 | 0 | -1 |  | 16 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 19:36 | 10/1/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Wender Joseph H | CA | D |  | 3 | S.m | -4,325 | 59.41 | 0 | -73 |  | 109 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 19:24 | 10/1/25 | TERN | Terns Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Kuriakose Emil | CA | O | Chief Me | 1 | S | -7 | 7.85 | 0 | -1 |  | 52 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 17:04 | 10/1/25 | AMPH | Amphastar Pharmaceuticals, Inc. |  | Health | Drug | Pharmaceutical Preparations | Petersen Floyd F. | CA | D |  | 3 | S | -40 | 26.34 | 0 | -2 |  | 77 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:47 | 9/30/25 | KALA | Kala Bio, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Baker Bros. Advisors LP | NY | H | Former 1 | 1 | S.m | -1,057 | 1.45 | 0 | -730 |  | 425 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Klee Justin B. | MA | DO | Co-CEO | 1 | S | -431 | 14.38 | 0 | -30 |  | 3,325 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Mazzariello Gina | MA | O | GC | 2 | S.m | -375 | 9.65 | 0 | -39 |  | 157 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Frates James M | MA | O | CFO | 1 | S | -155 | 14.65 | 0 | -11 |  | 307 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Cohen Joshua B | MA | DO | Co-CEO | 1 | S | -429 | 14.35 | 0 | -30 |  | 3,325 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/2/25 16:15 | 9/30/25 | AMLX | Amylyx Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bedrosian Camille L | MA | O | Chief Me | 1 | S | -176 | 14.58 | 0 | -12 |  | 182 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 20:14 | 8/25/25 | NUVL | Nuvalent, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Noci Darlene | MA | O | Chief De | 2 | S.d | -631 | 78.85 | 0 | -8 |  | 48 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 19:17 | 10/1/25 | XENE | Xenon Pharmaceuticals Inc. | A1 | Health | Drug | Pharmaceutical Preparations | Mortimer Ian | A1 | DO | P,CEO,IN | 1 | S.d | -1,004 | 40.16 | 0 | -25 |  | 46 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 17:22 | 9/29/25 | MLTX | Moonlake Immunotherapeutics | E9 | Health | Drug | Pharmaceutical Preparations | Chen Bihua | MA | H | Former 1 | 1 | S.m | -46,868 | 7.21 | 0 | -6,500 |  | 1,994 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 17:16 | 9/29/25 | PGEN | Precigen, Inc. | VA | Health | Drug | Pharmaceutical Preparations | Kindler Jeffrey B | MD | D |  | 1 | S.m | -604 | 3.47 | 0 | -174 |  | 346 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:57 | 9/29/25 | BCAX | Bicara Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Meisner Lara | MA | O | GC | 2 | S.d | -681 | 13.71 | 0 | -50 | -100 | 0 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:55 | 9/30/25 | IONS | Ionis Pharmaceuticals Inc | CA | Health | Drug | Pharmaceutical Preparations | Geary Richard S | CA | O | EVP,Chie | 3 | S.d | -4,710 | 60.46 | 0 | -78 |  | 89 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:46 | 9/29/25 | ELVN | Enliven Therapeutics, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Hohl Benjamin | CO | O | CFO | 2 | S.d | -133 | 20.51 | 0 | -7 |  | 23 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:30 | 9/29/25 | ABEO | Abeona Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | O'Malley Brendan M. | OH | O | SVP,GC | 2 | S | -54 | 5.40 | 0 | -10 |  | 360 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:30 | 9/29/25 | ABEO | Abeona Therapeutics Inc. | DE | Health | Drug | Pharmaceutical Preparations | Vazzano Joseph Walter | OH | O | CFO | 2 | S | -159 | 6.62 | 0 | -24 |  | 463 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:24 | 10/1/25 | RMTI | Rockwell Medical, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Chole Timothy | MI | O | SVP,CCO | 1 | S | -3 | 1.19 | 0 | -3 |  | 125 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:23 | 10/1/25 | RMTI | Rockwell Medical, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Neri Jesse | MI | O | SVP,CFO | 1 | S | -1 | 1.19 | 0 | -1 |  | 126 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:22 | 10/1/25 | RMTI | Rockwell Medical, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Strobeck Mark | MI | DO | P,CEO | 1 | S | -8 | 1.19 | 0 | -7 |  | 331 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 10/1/25 16:00 | 9/30/25 | ANAB | Anaptysbio, Inc | DE | Health | Drug | Pharmaceutical Preparations | Loumeau Eric J | CA | O | GC | 1 | S.d | -239 | 29.00 | 0 | -8 |  | 9 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 18:59 | 9/29/25 | RCUS | Arcus Biosciences, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Azoy Alexander | CA | O | Chief Ac | 2 | S | -56 | 12.60 | 0 | -4 |  | 30 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 17:56 | 9/26/25 | AGIO | Agios Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Jones Cecilia | MA | O | CFO | 1 | S.d | -134 | 36.77 | 0 | -4 |  | 34 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 17:44 | 9/30/25 | PGEN | Precigen, Inc. | VA | Health | Drug | Pharmaceutical Preparations | Kirk Randal J | VA | DT |  | 2 | S.dm | -24,824 | 3.65 | 0 | -6,810 |  | 128,722 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 16:42 | 9/26/25 | CRNX | Crinetics Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Struthers Richard Scott | CA | DO | P,CEO | 1 | S | -180 | 45.00 | 0 | -4 | 0 | 1,298 | I |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/30/25 16:41 | 9/26/25 | CRNX | Crinetics Pharmaceuticals, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Fust Matthew K | CA | D |  | 1 | S.d | -716 | 44.75 | 0 | -16 |  | 23 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/29/25 19:30 | 9/29/25 | KURA | Kura Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Powl Brian T. | CA | O | Chief Co | 1 | S | -80 | 8.94 | 0 | -9 |  | 100 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/29/25 19:30 | 9/29/25 | KURA | Kura Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Bair Teresa Brophy | CA | O | GC | 1 | S | -79 | 8.94 | 0 | -9 |  | 148 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 
| 9/29/25 19:30 | 9/29/25 | KURA | Kura Oncology, Inc. | DE | Health | Drug | Pharmaceutical Preparations | Ford Kathleen | CA | O | COO | 1 | S | -62 | 8.94 | 0 | -7 |  | 63 | D |  |  |  |  |  |  |  |  |  |  |  |  |  |  |