SEC Form 4	Date	Sym	Company	Insider	Title	Shares	Transaction	Value
May 24 07:20am	MMay 23 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	37,000	Purchase at $6.97	$257,882
May 23 04:15pm	May 22 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	15,000	Purchase at $6.45	$96,759
May 23 09:14am	MMay 22 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	42,300	Purchase at $6.88	$290,910
May 22 09:53am	MMay 21 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	73,500	Purchase at $6.99	$514,081
May 21 07:09am	MMay 20 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	54,400	Purchase at $7.07	$384,811
May 20 07:29am	MMay 17 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	27,200	Purchase at $7.12	$193,636
May 17 04:20pm	May 16 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	3,000	Purchase at $6.39	$19,156
May 17 09:26am	MMay 16 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	59,100	Purchase at $7.02	$414,987
May 16 04:17pm	May 15 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	6,600	Purchase at $6.50	$42,924
May 16 08:20am	MMay 15 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	13,300	Purchase at $7.11	$94,578
May 15 04:15pm	May 14 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	4,000	Purchase at $6.33	$25,336
May 15 09:02am	MMay 14 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	35,100	Purchase at $6.93	$243,339
May 14 04:27pm	May 13 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	5,000	Purchase at $6.23	$31,149
May 14 08:41am	MMay 13 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	46,900	Purchase at $6.85	$321,326
May 13 06:53am	MMay 10 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	10,500	Purchase at $6.86	$72,039
May 10 04:15pm	May 9 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	15,800	Purchase at $6.23	$98,390
May 10 07:45am	MMay 9 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	10,700	Purchase at $6.78	$72,515
May 9 04:19pm	May 8 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	25,400	Purchase at $6.19	$157,348
May 9 09:22am	MMay 8 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	42,000	Purchase at $6.69	$281,030
May 8 04:22pm	May 7 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	3,000	Purchase at $6.25	$18,735
May 8 11:06am	MMay 7 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	22,500	Purchase at $6.76	$152,131
May 7 05:03pm	May 6 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	11,000	Purchase at $6.18	$67,973
May 7 08:43am	MMay 6 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	23,800	Purchase at $6.69	$159,250
May 6 10:27am	MMay 3 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	27,500	Purchase at $6.69	$183,902
May 6 09:01am	MMay 2 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	27,000	Purchase at $6.23	$168,245
May 3 09:51am	MMay 2 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	80,000	Purchase at $6.56	$524,888
May 2 04:32pm	Apr 30 2013	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	10,000	Purchase at $6.25	$62,510
May 2 09:32am	MMay 1 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	72,500	Purchase at $6.43	$465,953
May 1 08:21am	MApr 30 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	45,000	Purchase at $6.69	$300,955
Apr 30 08:46am	MApr 29 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	25,000	Purchase at $6.86	$171,592
Apr 29 08:53am	MApr 26 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	50,000	Purchase at $6.92	$345,964
Apr 25 11:52am	MApr 24 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	100,000	Purchase at $6.92	$692,447
Apr 16 08:44am	MApr 15 2013	LTS	Ladenburg Thalmann Financial Services Inc	Frost Phillip Md Et Al	Director, 10% Owner	10,000	Purchase at $1.45	$14,500
Apr 11 07:42am	MApr 10 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	20,000	Purchase at $7.10	$141,910
Apr 10 08:54am	MApr 9 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	250,600	Purchase at $6.95	$1,742,005
Apr 10 07:02am	Apr 8 2013	NIMU	Non Invasive Monitoring Systems Inc /fl/	Frost Phillip Md Et Al	10% Owner	2,000,000	Purchase at $0.05	$100,000
Apr 8 08:59am	MApr 4 2013	LTS	Ladenburg Thalmann Financial Services Inc	Frost Phillip Md Et Al	Director, 10% Owner	15,000	Purchase at $1.61	$24,192
Apr 8 08:55am	MApr 5 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	28,000	Purchase at $7.18	$200,914
Apr 5 08:34am	MApr 4 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	22,200	Purchase at $7.15	$158,728
Apr 4 09:28am	MApr 3 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	156,500	Purchase at $6.96	$1,089,197
Apr 3 08:43am	MApr 2 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	91,900	Purchase at $7.42	$681,642
Apr 2 08:56am	MApr 1 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	66,900	Purchase at $7.45	$498,607
Apr 1 08:51am	MMar 28 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	16,500	Purchase at $7.60	$125,453
Mar 28 08:16am	MMar 27 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	22,900	Purchase at $7.59	$173,856
Mar 27 09:43am	MMar 26 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	22,500	Purchase at $7.63	$171,604
Mar 27 09:20am	Mar 26 2013	LTS	Ladenburg Thalmann Financial Services Inc	Frost Phillip Md Et Al	Director, 10% Owner	10,000	Purchase at $1.60	$16,000
DMar 26 04:22pm	Mar 22 2013	SFES	Safestitch Medical, Inc.	Frost Phillip Md Et Al	10% Owner	2,000,000	Purchase at $0.25	$500,000
Mar 26 07:49am	MMar 25 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	31,600	Purchase at $7.55	$238,424
Mar 25 08:55am	MMar 22 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	14,500	Purchase at $7.60	$110,225
Mar 22 09:17am	MMar 21 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	68,500	Purchase at $7.37	$504,752
Mar 21 04:05pm	MMar 19 2013	LTS	Ladenburg Thalmann Financial Services Inc	Frost Phillip Md Et Al	Director, 10% Owner	15,000	Purchase at $1.66	$24,919
DMar 20 08:50am	MMar 19 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	48,300	Purchase at $7.52	$363,403
Mar 19 08:31am	MMar 18 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	42,800	Purchase at $7.63	$326,479
Mar 18 05:24pm	MMar 15 2013	ROX	Castle Brands Inc	Frost Phillip Md Et Al	Director, 10% Owner	58,600	Purchase at $0.27	$15,822
Mar 15 07:13am	MMar 14 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	32,700	Purchase at $7.54	$246,485
Mar 14 11:10am	MMar 13 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	37,100	Purchase at $6.96	$258,313
Mar 13 08:13am	MMar 12 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	23,500	Purchase at $7.48	$175,751
Mar 12 04:49pm	Mar 8 2013	ROX	Castle Brands Inc	Frost Phillip Md Et Al	Director, 10% Owner	5,500	Purchase at $0.27	$1,485
DMar 12 11:22am	Mar 8 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	2,520,190	Option exercise at $0.00	$0
DMar 12 11:22am	MMar 11 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	38,000	Purchase at $7.45	$283,117
Mar 11 09:57am	MMar 8 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	43,000	Purchase at $7.33	$315,264
Mar 8 06:49am	MMar 7 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	51,500	Purchase at $7.36	$378,817
Mar 7 04:50pm	MMar 5 2013	ROX	Castle Brands Inc	Frost Phillip Md Et Al	Director, 10% Owner	5,805	Purchase at $0.27	$1,567
Mar 7 10:15am	MMar 6 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	44,000	Purchase at $7.30	$321,360
Mar 6 09:12am	MMar 5 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	52,000	Purchase at $7.28	$378,473
Mar 5 09:33am	MMar 4 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	35,500	Purchase at $7.10	$252,058
Mar 4 10:26am	MMar 1 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	20,000	Purchase at $7.00	$140,098
Mar 1 09:29am	MFeb 28 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	72,500	Purchase at $6.99	$506,835
Feb 28 04:08pm	MFeb 26 2013	ROX	Castle Brands Inc	Frost Phillip Md Et Al	Director, 10% Owner	100,000	Purchase at $0.27	$27,000
Feb 28 10:05am	MFeb 27 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	55,000	Purchase at $7.07	$388,599
Feb 27 07:42am	MFeb 26 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	65,000	Purchase at $6.99	$454,329
Feb 26 08:12am	MFeb 25 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	35,000	Purchase at $7.09	$248,275
Feb 25 09:33am	MFeb 22 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	45,000	Purchase at $7.03	$316,539
Feb 22 08:24am	MFeb 21 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	10,000	Purchase at $6.68	$66,754
Feb 21 10:14am	MFeb 20 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	88,000	Purchase at $6.65	$585,484
Feb 20 09:03am	MFeb 19 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	25,000	Purchase at $6.74	$168,553
Feb 19 07:30am	MFeb 15 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	57,500	Purchase at $6.74	$387,393
Feb 15 10:11am	MFeb 14 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	40,000	Purchase at $6.84	$273,436
Feb 14 09:30am	MFeb 13 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	20,000	Purchase at $6.67	$133,335
Feb 13 09:35am	MFeb 12 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	45,000	Purchase at $6.69	$301,261
Feb 11 12:07pm	MFeb 8 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	110,000	Purchase at $6.33	$696,818
Feb 8 08:48am	MFeb 7 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	37,500	Purchase at $6.85	$256,893
Feb 7 09:32am	MFeb 6 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	30,000	Purchase at $6.90	$206,953
Feb 1 04:42pm	Jan 30 2013	CDOM	Tiger X Medical, Inc.	Frost Phillip Md Et Al	10% Owner	194,685	Purchase at $0.07	$13,628
Feb 1 11:40am	MJan 31 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	40,000	Purchase at $6.46	$258,400
Jan 16 07:35am	MJan 15 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	35,000	Purchase at $5.70	$199,642
Jan 15 08:35am	MJan 14 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	20,000	Purchase at $5.63	$112,659
Jan 14 09:32am	MJan 11 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	30,000	Purchase at $5.35	$160,586
Jan 11 08:23am	MJan 10 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	46,000	Purchase at $5.28	$242,997
Jan 10 08:31am	MJan 9 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	50,000	Purchase at $5.20	$260,215
Jan 8 04:15pm	Dec 28 2012	PBTH	Prolor Biotech, Inc.	Frost Phillip Md Et Al	Director, 10% Owner	2,934,852	Gift at $0.00	$0
Jan 7 08:26am	MJan 4 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	40,000	Purchase at $5.16	$206,385
Jan 4 09:36am	MJan 3 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	25,000	Purchase at $5.03	$125,766
Jan 3 10:13am	MJan 2 2013	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	30,000	Purchase at $4.99	$149,683
Jan 2 09:10am	MDec 28 2012	LTS	Ladenburg Thalmann Financial Services Inc	Frost Phillip Md Et Al	Director, 10% Owner	85,000	Purchase at $1.35	$114,910
Jan 2 08:11am	MDec 31 2012	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	100,000	Purchase at $4.78	$478,224
Dec 31 2012	MDec 28 2012	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	55,000	Purchase at $4.75	$261,133
Dec 28 2012	MDec 27 2012	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	25,000	Purchase at $4.72	$117,889
Dec 27 2012	MDec 26 2012	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	85,000	Purchase at $4.68	$397,470
Dec 26 2012	MDec 24 2012	OPK	Opko Health, Inc.	Frost Phillip Md Et Al	CEO, Chairman, 10% Owner	30,000	Purchase at $4.63	$139,012

^D Derivative transaction exists
^M Multiple transactions summarized; earliest reported transaction date and average weighted transaction price
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